Oxybutynin chloride topical gel: a new formulation of an established antimuscarinic therapy for overactive bladder
| العنوان: | Oxybutynin chloride topical gel: a new formulation of an established antimuscarinic therapy for overactive bladder |
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| المؤلفون: | David R. Staskin, Dudley Robinson |
| المصدر: | Expert Opinion on Pharmacotherapy. 10:3103-3111 |
| بيانات النشر: | Informa Healthcare, 2009. |
| سنة النشر: | 2009 |
| مصطلحات موضوعية: | medicine.medical_specialty, medicine.drug_class, Chemistry, Pharmaceutical, Urology, Urinary incontinence, Muscarinic Antagonists, Pharmacology, Administration, Cutaneous, Oxybutynin Chloride, medicine, Anticholinergic, Humans, Pharmacology (medical), Oxybutynin, Adverse effect, Transdermal, Urinary Bladder, Overactive, business.industry, General Medicine, medicine.disease, Clinical trial, Treatment Outcome, Clinical Trials, Phase III as Topic, Overactive bladder, Mandelic Acids, medicine.symptom, business, Gels, medicine.drug |
| الوصف: | Oxybutynin, a cholinergic-muscarinic receptor antagonist, is established as a safe and effective pharmacological treatment for patients with overactive bladder syndrome (OAB). Oxybutynin is available in multiple immediate- and extended-release oral and two transdermal formulations. Oxybutynin chloride topical gel (OTG) (Gelnique), Watson Pharmaceuticals, Corona, CA, USA) was approved in January 2009 by the US FDA. OTG was designed to provide consistent plasma oxybutynin levels with daily application, favorably altering the circulating N-desethyloxybutynin metabolite:oxybutynin ratio, and to utilize a biocompatible delivery system, thus minimizing both the anticholinergic adverse effects of oral formulations and the application-site skin reactions associated with other available forms of transdermal delivery.This review summarizes the pharmacological properties and the clinical efficacy and safety profile of OTG based on the published literature and unpublished data provided by the manufacturer upon request.OTG represents an efficacious, safe, and convenient alternative to other oxybutynin formulations and other oral anticholinergic medications for the treatment of OAB. Future studies and broad clinical experience should confirm the promising early experience observed with this formulation. |
| تدمد: | 1744-7666 1465-6566 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::161a5ad19784503c752e185db409e2efTest https://doi.org/10.1517/14656560903451682Test |
| رقم الانضمام: | edsair.doi.dedup.....161a5ad19784503c752e185db409e2ef |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17447666 14656566 |
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