Predicting Non-Alcoholic Fatty Liver Disease Progression and Immune Deregulations by Specific Gene Expression Patterns
| العنوان: | Predicting Non-Alcoholic Fatty Liver Disease Progression and Immune Deregulations by Specific Gene Expression Patterns |
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| المؤلفون: | Fanhong Zeng, Yue Zhang, Xu Han, Min Zeng, Yi Gao, Jun Weng |
| المصدر: | Frontiers in Immunology Frontiers in Immunology, Vol 11 (2021) |
| بيانات النشر: | Frontiers Media SA, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | lcsh:Immunologic diseases. Allergy, Adult, Liver Cirrhosis, Male, 0301 basic medicine, Carcinoma, Hepatocellular, Cirrhosis, Adolescent, Immunology, immune microenvironment, Gene Expression, digestive system, Young Adult, 03 medical and health sciences, Liver disease, 0302 clinical medicine, Immune system, Insulin resistance, Non-alcoholic Fatty Liver Disease, medicine, Humans, Immunology and Allergy, drug sensitivity, Aged, Original Research, Inflammation, B-Lymphocytes, Aldo-Keto Reductase Family 1 member B10, business.industry, Liver Neoplasms, Fatty liver, nutritional and metabolic diseases, Middle Aged, signature classifiers, Gene signature, medicine.disease, digestive system diseases, 030104 developmental biology, Liver, Disease Progression, Cytokines, Female, 030211 gastroenterology & hepatology, Metabolic syndrome, Steatohepatitis, lcsh:RC581-607, business |
| الوصف: | Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease worldwide with rising rates in parallel to obesity, type 2 diabetes, and metabolic syndrome. NAFLD includes pathologies ranging from simple steatosis (NAFL) to non-alcoholic steatohepatitis and cirrhosis (NASH), which may eventually develop into hepatocellular carcinoma (HCC). Mechanically, lipids accumulation and insulin resistance act as the first hit, inflammation and fibrosis serve as the second hit. Currently, the diagnosis of NAFLD mainly depends on pathology examination and medical imaging, whereas proper gene signature classifiers are necessary for the evaluation of disease status. Here, we developed three signature classifiers to distinguish different NAFLD disease states (NAFL and NASH). Moreover, we found that B cells, DCs, and MAIT cells are key deregulated immune cells in NAFLD, which are associated with NAFLD and NAFLD-HCC progression. Meanwhile, AKR1B10 and SPP1 are closely related to the above three immune cell infiltrations and immunosuppressive cytokines expressions in NAFLD and NAFLD-HCC. Subsequently, we screened out AKR1B10 and SPP1 sensitive molecules TGX-221, which may provide a possible therapy for NAFLD and NAFLD-HCC. |
| تدمد: | 1664-3224 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1586be56ec945e2833c5040a030bcf3dTest https://doi.org/10.3389/fimmu.2020.609900Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....1586be56ec945e2833c5040a030bcf3d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16643224 |
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