Causes of macrocytic anemia among 628 patients: mean corpuscular volumes of 114 and 130 fL as critical markers for categorization
| العنوان: | Causes of macrocytic anemia among 628 patients: mean corpuscular volumes of 114 and 130 fL as critical markers for categorization |
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| المؤلفون: | Riko Honma, Naoto Takahashi, Hisayuki Yokoyama, Hideo Harigae, Yoji Ishida, Yoshiko Tamai, Yuichi Kato, Yasuo Tomiya, Junichi Kameoka, Kazunori Murai, Kenichi Sawada, Kenichi Ishizawa, Hideyoshi Noji, Shigeki Ito, Natsuko Takahashi |
| المصدر: | International Journal of Hematology. 104:344-357 |
| بيانات النشر: | Springer Science and Business Media LLC, 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | Erythrocyte Indices, Hemolytic anemia, medicine.medical_specialty, Pathology, Anemia, Megaloblastic, Hemoglobinuria, Paroxysmal, Macrocytosis, Gastroenterology, 03 medical and health sciences, 0302 clinical medicine, Neoplasms, hemic and lymphatic diseases, Internal medicine, medicine, Humans, Anemia, Macrocytic, 030212 general & internal medicine, Vitamin B12, Aplastic anemia, Megaloblastic anemia, Bone Marrow Diseases, Mean corpuscular volume, Retrospective Studies, medicine.diagnostic_test, business.industry, Myelodysplastic syndromes, Anemia, Aplastic, Hematology, Bone Marrow Failure Disorders, medicine.disease, 030220 oncology & carcinogenesis, Macrocytic anemia, business |
| الوصف: | There have been no studies on the distribution of causes of macrocytic anemia with respect to mean corpuscular volume (MCV) cutoff values. We retrospectively investigated the causes of macrocytic anemia (MCV ≥100 fL) among 628 patients who visited the outpatient hematology clinic in Tohoku University Hospital. To ensure data validity, we also analyzed data from 307 patients in eight other hospitals in the Tohoku district. The leading causes of macrocytic anemia (number of patients, %) were myelodysplastic syndromes (121, 19.3 %), suspected bone marrow failure syndromes (BMF; 74, 11.8 %), aplastic anemia (51, 8.1 %), plasma cell dyscrasia (45, 7.2 %), and vitamin B12 deficiency (40, 6.4 %) in Tohoku University Hospital. We made three primary findings as follows. First, the most common cause of macrocytic anemia is BMF. Second, lymphoid and solid malignancies are also common causes of macrocytosis. Third, macrocytic anemia may be classified into three groups: Group 1 (megaloblastic anemia and medications), which can exceed MCV 130 fL; Group 2 (alcoholism/liver disease, BMF, myeloid malignancy, and hemolytic anemia), which can exceed MCV 114 fL; and Group 3 (lymphoid malignancy, chronic renal failure, hypothyroidism, and solid tumors), which does not exceed MCV 114 fL. These conclusions were supported by the results from eight other hospitals. |
| تدمد: | 1865-3774 0925-5710 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14dc7fce9c2ee472dffc23c3fcd629baTest https://doi.org/10.1007/s12185-016-2043-xTest |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....14dc7fce9c2ee472dffc23c3fcd629ba |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 18653774 09255710 |
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