Profile of patients with Brugada syndrome presenting with their first documented arrhythmic event: Data from the Survey on Arrhythmic Events in BRUgada Syndrome (SABRUS)
| العنوان: | Profile of patients with Brugada syndrome presenting with their first documented arrhythmic event: Data from the Survey on Arrhythmic Events in BRUgada Syndrome (SABRUS) |
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| المؤلفون: | Jimmy J.M. Juang, Kenzo Hirao, Yanushi D. Wijeyeratne, Antoine Leenhardt, Josep Brugada, Frederic Sacher, Pedro Brugada, Bernard Belhassen, Carla Giustetto, Silvia G. Priori, Yuka Mizusawa, Ruben Casado-Arroyo, Zhengrong Huang, Jacob Tfelt-Hansen, Arthur A.M. Wilde, Antoine Andorin, Shingo Maeda, Masahiko Takagi, Elijah R. Behr, Yoav Michowitz, Eran Leshem, Aviram Hochstadt, Vincent Probst, Carlo Napolitano, Giulio Conte, Michael Rahkovich, Isabelle Denjoy, Jean-Baptiste Gourraud, Pieter G. Postema, Tsukasa Kamakura, Fiorenzo Gaita, Jean Champagne, Gi-Byoung Nam, Philippe Mabo, Ramon Brugada, Yoshihide Takahashi, Gan-Xin Yan, Georgia Sarquella-Brugada, Leonardo Calo, Pietro Delise, Sung Hwan Kim, Domenico Corrado, Takeshi Aiba, Kengo Kusano, Christian Veltmann, Anat Milman, Elena Arbelo |
| المساهمون: | Faculty of Medicine and Pharmacy, Medicine and Pharmacy academic/administration, Cardio-vascular diseases, Clinical sciences |
| المصدر: | Heart Rhythm r-FSJD: Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu Fundació Sant Joan de Déu r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu instname |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | Male, Time Factors, 030204 cardiovascular system & hematology, Group A, electrophysiologic study, Group B, Sudden cardiac death, Electrocardiography, arrhythmic risk stratification, 0302 clinical medicine, Japan, Surveys and Questionnaires, Medicine, genetics, 030212 general & internal medicine, Family history, Israel, China/epidemiology, Brugada syndrome, Brugada Syndrome, Survival Rate/trends, medicine.diagnostic_test, Incidence (epidemiology), Incidence, Quebec, Middle Aged, United States/epidemiology, Prognosis, Defibrillators, Implantable, Japan/epidemiology, Europe, Survival Rate, Female, Cardiology and Cardiovascular Medicine, Adult, medicine.medical_specialty, China, Adolescent, Risk Assessment, sudden cardiac death, Europe/epidemiology, 03 medical and health sciences, Electrophysiology study, Young Adult, Physiology (medical), Internal medicine, Republic of Korea, Arrhythmic risk stratification, Electrophysiologic study, Genetics, ICD, Humans, Death, Sudden, Cardiac/epidemiology, Israel/epidemiology, Aged, business.industry, medicine.disease, United States, Brugada Syndrome/complications, Death, Sudden, Cardiac, Event data, Republic of Korea/epidemiology, business, Quebec/epidemiology |
| الوصف: | BACKGROUND: Detailed information on the profile of patients with Brugada syndrome (BrS) presenting their first arrhythmic event (AE) after prophylactic implantation of an implantable cardioverter-defibrillator (ICD) is limited. OBJECTIVES: The objectives of this study were (1) to compare clinical, electrocardiographic, electrophysiologic, and genetic profiles of patients who exhibited their first documented AE as aborted cardiac arrest (group A) with profiles of those in whom the AE was documented after prophylactic ICD implantation (group B) and (2) to characterize group B patients' profile using the class II indications for ICD implantation established by HRS/EHRA/APHRS expert consensus statement in 2013. METHODS: A survey of 23 centers from 10 Western and 4 Asian countries enabled data collection of 678 patients with BrS who exhibited their AE (group A, n = 426; group B, n = 252). RESULTS: The first AE occurred in group B patients 6.7 years later than in group A (mean age 46.1 ± 13.3 years vs 39.4 ± 15.1 years; P < .001). Group B patients had a higher incidence of family history of sudden cardiac death and SCN5A mutations. Of the 252 group B patients, 189 (75%) complied with the HRS/EHRA/APHRS indications whereas the remaining 63 (25%) did not. CONCLUSION: Patients with BrS with the first AE documented after prophylactic ICD implantation exhibited their AE at a later age with a higher incidence of positive family history of sudden cardiac death and SCN5A mutations as compared with those presenting with aborted cardiac arrest. Only 75% of patients who exhibited an AE after receiving a prophylactic ICD complied with the 2013 class II indications, suggesting that efforts are still required for improving risk stratification. |
| تدمد: | 1556-3871 1547-5271 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::148c16706c5a13a63d89880fe814a0c9Test https://pubmed.ncbi.nlm.nih.gov/29325976Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....148c16706c5a13a63d89880fe814a0c9 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15563871 15475271 |
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