Regulation of ER-phagy by a Ypt/Rab GTPase module
| العنوان: | Regulation of ER-phagy by a Ypt/Rab GTPase module |
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| المؤلفون: | Zhanna Lipatova, Jonathan W. Mulholland, Nava Segev, Ankur H. Shah, Jane J. Kim |
| المصدر: | Molecular Biology of the Cell |
| سنة النشر: | 2013 |
| مصطلحات موضوعية: | Saccharomyces cerevisiae Proteins, Golgi Apparatus, GTPase, Saccharomyces cerevisiae, Biology, Endoplasmic Reticulum, 03 medical and health sciences, symbols.namesake, 0302 clinical medicine, Lysosome, Gene Expression Regulation, Fungal, medicine, Autophagy, Molecular Biology, 030304 developmental biology, 0303 health sciences, Endoplasmic reticulum, Membrane Proteins, Cell Biology, Articles, Golgi apparatus, Cell biology, Transport protein, Protein Transport, medicine.anatomical_structure, rab GTP-Binding Proteins, Membrane Trafficking, Mutation, Proteolysis, symbols, Unfolded protein response, Rab, Lysosomes, 030217 neurology & neurosurgery |
| الوصف: | Ypt1 GTPase, in the context of an autophagy-specific module, regulates ER-phagy. Because Ypt1 is a known regulator of ER-to-Golgi transport, this means that a single Ypt/Rab can regulate two alternative transport steps from one compartment, the ER, to two different destinations, the Golgi and the autophagy pathway. Accumulation of misfolded proteins on intracellular membranes has been implicated in neurodegenerative diseases. One cellular pathway that clears such aggregates is endoplasmic reticulum autophagy (ER-phagy), a selective autophagy pathway that delivers excess ER to the lysosome for degradation. Not much is known about the regulation of ER-phagy. The conserved Ypt/Rab GTPases regulate all membrane trafficking events in eukaryotic cells. We recently showed that a Ypt module, consisting of Ypt1 and autophagy-specific upstream activator and downstream effector, regulates the onset of selective autophagy in yeast. Here we show that this module acts at the ER. Autophagy-specific mutations in its components cause accumulation of excess membrane proteins on aberrant ER structures and induction of ER stress. This accumulation is due to a block in transport of these membranes to the lysosome, where they are normally cleared. These findings establish a role for an autophagy-specific Ypt1 module in the regulation of ER-phagy. Moreover, because Ypt1 is a known key regulator of ER-to-Golgi transport, these findings establish a second role for Ypt1 at the ER. We therefore propose that individual Ypt/Rabs, in the context of distinct modules, can coordinate alternative trafficking steps from one cellular compartment to different destinations. |
| تدمد: | 1939-4586 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1484d74c6534006210bb0a7ffbde1d9fTest https://pubmed.ncbi.nlm.nih.gov/23924895Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....1484d74c6534006210bb0a7ffbde1d9f |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19394586 |
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