Role of muscarinic receptor antagonists in urgency and nocturia
| العنوان: | Role of muscarinic receptor antagonists in urgency and nocturia |
|---|---|
| المؤلفون: | Jean J.M.C.H. de la Rosette, Martin C. Michel |
| المصدر: | BJU International. 96:37-42 |
| بيانات النشر: | Wiley, 2005. |
| سنة النشر: | 2005 |
| مصطلحات موضوعية: | medicine.medical_specialty, Urology, Muscarinic Antagonists, urologic and male genital diseases, Placebo, Sex Factors, Behavior Therapy, Muscarinic acetylcholine receptor, medicine, Darifenacin, Humans, Nocturia, Randomized Controlled Trials as Topic, Solifenacin, business.industry, Age Factors, Antagonist, Urination Disorders, medicine.disease, female genital diseases and pregnancy complications, Urinary Incontinence, Overactive bladder, Tolterodine, medicine.symptom, business, Forecasting, medicine.drug |
| الوصف: | The overactive bladder (OAB) syndrome is defined as urgency, with or without urgency incontinence, usually accompanied by frequency and nocturia. Muscarinic receptor antagonists are the most established form of treatment for OAB, but until recently their effectiveness was only confirmed for symptoms of incontinence and frequency. In recent studies, selected muscarinic antagonists, including darifenacin, solifenacin, tolterodine and trospium, significantly reduced the number of urgency episodes per day relative to placebo. While some data raise the possibility that certain of these agents may be more effective than others in this regard, this variability in their effect on urgency needs to be confirmed in future studies. Moreover, it remains to be determined whether counting the number of urgency episodes or assessing the subjective intensity of the sensation of urgency more adequately reflects patient needs and therapeutic efficacy. For nocturia, muscarinic receptor antagonists have only inconsistently shown statistically greater effects than placebo. This inconsistency may relate to the multifactorial nature of nocturia, which even in patients with OAB can have many causes, not all of which may respond/be sensitive to muscarinic receptor antagonism. |
| تدمد: | 1464-410X 1464-4096 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1460601a8464ae7c24470b24232ef74eTest https://doi.org/10.1111/j.1464-410x.2005.05651.xTest |
| حقوق: | RESTRICTED |
| رقم الانضمام: | edsair.doi.dedup.....1460601a8464ae7c24470b24232ef74e |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1464410X 14644096 |
|---|