Respiratory Tract Secretions in the Dying Patient: A Comparison between Glycopyrronium and Hyoscine Hydrobromide
| العنوان: | Respiratory Tract Secretions in the Dying Patient: A Comparison between Glycopyrronium and Hyoscine Hydrobromide |
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| المؤلفون: | John Ellershaw, Heino Hugel, Maureen Gambles |
| المصدر: | Journal of Palliative Medicine. 9:279-284 |
| بيانات النشر: | Mary Ann Liebert Inc, 2006. |
| سنة النشر: | 2006 |
| مصطلحات موضوعية: | Male, Drug, media_common.quotation_subject, Respiratory System, Scopolamine, Muscarinic Antagonists, Overall response rate, medicine, Humans, Terminally Ill, Symptom control, Death rattle, General Nursing, Specialist palliative care, Aged, media_common, Aged, 80 and over, business.industry, Hydrobromide, Significant difference, General Medicine, Middle Aged, Glycopyrrolate, Treatment Outcome, Anesthesiology and Pain Medicine, medicine.anatomical_structure, Anesthesia, Female, medicine.symptom, business, Respiratory tract |
| الوصف: | The evidence for the management of respiratory tract secretions (RTS) in dying patients with antimuscarinic drugs remains inconclusive. This study investigated the effectiveness of glycopyrronium versus hyoscine hydrobromide in controlling RTS using the Liverpool Care of the Dying Pathway (LCP) in 72 patients matched for age, diagnosis, and gender who died on a 30-bed specialist palliative care unit. All patients in the glycoypyrronium group had some response to glycopyrronium, whereas 22% of patients in the hyoscine group had no response to hyoscine hydrobromide. There was a significant difference in overall response between the two groups (p0.01). Twenty-eight percent of patients in the glycopyrronium and 42% of patients in the hyoscine group died with RTS present. There was no statistically significant difference in the levels of agitation following administration of either drug. This study provides further evidence that the LCP can be a useful tool in the evaluation of new drugs for symptom control in dying patients and suggests that glycopyrronium may be at least as effective in controlling RTS in dying patients as hyoscine hydrobromide. |
| تدمد: | 1557-7740 1096-6218 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13f810ef6eea15e276678b55939ff568Test https://doi.org/10.1089/jpm.2006.9.279Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....13f810ef6eea15e276678b55939ff568 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15577740 10966218 |
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