| الوصف: |
The remarkable flurry in identification of chromatin-modifying activities in recent times has been accompanied by unexpected connections between these activities and cellular transformation. The possible link between Rb function as a tumor suppressor and the function of p48 as a “histone escort” is intriguing, but is at present very speculative. However, disruption of interactions between a Gcn5p (HAT A) homolog, P/CAF, and its cofactors, p300 or CBP, by the product of the viral E1A oncogene is required for E1A-mediated cellular transformation (Yang et al. 1996xYang, X.J, Ogryzko, V.V, Nishikawa, J, Howard, B.H, and Nakatani, Y. Nature. 1996; 382: 319–324CrossRef | PubMed | Scopus (1184)See all ReferencesYang et al. 1996). Translocation of another putative acetylase, MOZ, and in-frame fusion to CBP is associated with specific subtypes of acute myeloid leukemias (Borrow et al. 1996xBorrow, J, Stanton, V.P Jr., Andresen, J.M, Becher, R, Behm, F.G, Chaganti, R.S.K, Civin, C.I, Disteche, C, Dube, I, Frischauf, A.M, Horsman, D, Mitelman, F, Volina, S, Watmore, A.E, and Housman, D.E. Nature Genet. 1996; 13: 33–41CrossRef | Scopus (518)See all ReferencesBorrow et al. 1996). MOZ is homologous to the yeast gene SAS2 (Something About Silencing) which is required for silencing in yeast (Reifsnyder et al. 1996xReifsnyder, C, Lowell, J, Clarke, A, and Pillus, L. Nature Genet. 1996; 13: 42–49CrossRef | Scopus (212)See all ReferencesReifsnyder et al. 1996), suggesting the human gene may also participate in silencing functions. Understanding the nature, regulation, and specificity of these activities is no longer just the pursuit of those interested in understanding the structure and function of chromatin, but is now directly relevant to our understanding of both normal cellular regulatory processes and abnormal processes which lead to oncogenesis. |
