IDH mutation and 1p19q codeletion distinguish two radiological patterns of diffuse low-grade gliomas
| العنوان: | IDH mutation and 1p19q codeletion distinguish two radiological patterns of diffuse low-grade gliomas |
|---|---|
| المؤلفون: | Michel Fabbro, Yordanka Yordanova, Sonia Zouaoui, Emmanuelle Le Bars, Luc Bauchet, Hugues Duffau, Catherine Gozé, Amélie Darlix, Jeremy Deverdun, Florence Castan, Valérie Rigau, Nicolas Menjot de Champfleur |
| المساهمون: | UNICANCER - Institut régional du Cancer Montpellier Val d'Aurelle (ICM), CRLCC Val d'Aurelle - Paul Lamarque, Institut des Neurosciences de Montpellier - Déficits sensoriels et moteurs (INM), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Département de Neuroradiologie[Montpellier], Université Montpellier 1 (UM1)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Hôpital Gui de Chauliac [Montpellier]-Université de Montpellier (UM), Laboratoire Charles Coulomb (L2C), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Institut de Recherche en Cancérologie de Montpellier (IRCM - U1194 Inserm - UM), CRLCC Val d'Aurelle - Paul Lamarque-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Service de Neurochirurgie [Montpellier], CHU Gui de Chauliac [Montpellier]-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier) |
| المصدر: | Journal of Neuro-Oncology Journal of Neuro-Oncology, Springer Verlag, 2017, 133 (1), pp.37--45. ⟨10.1007/s11060-017-2421-0⟩ |
| بيانات النشر: | HAL CCSD, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | Male, Cancer Research, Pathology, Molecular biology, [SDV]Life Sciences [q-bio], Fluid-attenuated inversion recovery, computer.software_genre, 0302 clinical medicine, Voxel, Diffuse low-grade gliomas, 10. No inequality, Therapeutic strategy, medicine.diagnostic_test, Brain Neoplasms, Brain, Glioma, Middle Aged, Magnetic Resonance Imaging, Isocitrate Dehydrogenase, 3. Good health, Idh mutation, Tumor Burden, Isocitrate dehydrogenase, Neurology, Oncology, Chromosomes, Human, Pair 1, 030220 oncology & carcinogenesis, Radiological weapon, Female, Chromosome Deletion, Adult, medicine.medical_specialty, Adolescent, behavioral disciplines and activities, 03 medical and health sciences, Young Adult, 1p19q codeletion, medicine, Humans, Aged, Retrospective Studies, business.industry, Magnetic resonance imaging, IDH mutation, Mutation, Voxel-based lesion-symptom mapping, Neurology (clinical), Neoplasm Grading, business, computer, Chromosomes, Human, Pair 19, 030217 neurology & neurosurgery |
| الوصف: | International audience; Diffuse low-grade gliomas (DLGG) prognosis is variable, depending on several factors, including the isocitrate dehydrogenase (IDH) mutation and the 1p19q codeletion. A few studies suggested associations between these parameters and tumor radiological characteristics including topography. Our aim was analyzing the correlations between the IDH and 1p19q statuses and the tumor intracerebral distribution (at the lobar and voxel levels), volume, and borders. We conducted a retrospective, monocentric study on a consecutive series of 198 DLGG patients. The IDH and 1p19q statuses were recorded. The pre-treatment magnetic resonance FLAIR imagings were reviewed for determination of lobar topography, tumor volume, and characterisation of tumor borders (sharp or indistinct). We conducted a voxel-based lesion-symptom mapping analysis to investigate the correlations between the IDH and 1p19q statuses and topography at the voxel level. The IDH mutation and 1p19q statuses were correlated with the tumor topography defined using lobar anatomy (p \textless 0.001 and p = 0.004, respectively). Frontal tumors were more frequently IDH-mutant (87.1 vs. 57.4%) and 1p19q codeleted (45.2 vs. 17.0%) than temporo-insular lesions. At the voxel level, these associations were not found. Tumors with sharp borders were more frequently IDH-mutant (p = 0.001) while tumors with indistinct borders were more frequently IDH wild-type and 1p19q non-codeleted (p \textless 0.001). Larger tumors at diagnosis (possibly linked to a slower growth rate) were more frequently IDH-mutant (p \textless 0.001). IDH wild-type, 1p19q non-codeleted temporo-insular tumors are distinct from IDH-mutant, 1p19q codeleted frontal tumors. Further studies are needed to determine whether the therapeutic strategy should be adapted to each pattern. |
| اللغة: | English |
| تدمد: | 0167-594X 1573-7373 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::136953c44beae890b3b40c7eb9124a1cTest https://hal.archives-ouvertes.fr/hal-01792564Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....136953c44beae890b3b40c7eb9124a1c |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 0167594X 15737373 |
|---|