The mechanisms and treatments of muscular pathological changes in immobilization-induced joint contracture: A literature review
| العنوان: | The mechanisms and treatments of muscular pathological changes in immobilization-induced joint contracture: A literature review |
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| المؤلفون: | Yun Zhou, Feng Wang, Shuang Chen, Quan-Bing Zhang, Peng-Peng Huang, Yi Liu, Yuan-Hong Xu |
| المصدر: | Chinese Journal of Traumatology, Vol 22, Iss 2, Pp 93-98 (2019) Chinese Journal of Traumatology |
| بيانات النشر: | Elsevier, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Muscle tissue, Proteasome Endopeptidase Complex, Pathology, medicine.medical_specialty, Contracture, Connective tissue, Review, Transforming Growth Factor beta1, Skeletal muscle fibrosis, Immobilization, 03 medical and health sciences, 0302 clinical medicine, Fibrosis, Autophagy, medicine, Humans, Orthopedics and Sports Medicine, Joint Contracture, Muscle, Skeletal, Muscle contracture, 030222 orthopedics, lcsh:R5-920, Ubiquitin, business.industry, Skeletal muscle, 030208 emergency & critical care medicine, medicine.disease, Immobilization-induced joint contracture, Disuse skeletal muscle atrophy, Matrix Metalloproteinases, Treatment, medicine.anatomical_structure, Connective Tissue, Caspases, Proteolysis, Calcium, Joints, Surgery, Atrophy, medicine.symptom, Lysosomes, business, lcsh:Medicine (General), Signal Transduction |
| الوصف: | The clinical treatment of joint contracture due to immobilization remains difficult. The pathological changes of muscle tissue caused by immobilization-induced joint contracture include disuse skeletal muscle atrophy and skeletal muscle tissue fibrosis. The proteolytic pathways involved in disuse muscle atrophy include the ubiquitin-proteasome-dependent pathway, caspase system pathway, matrix metalloproteinase pathway, Ca2+-dependent pathway and autophagy-lysosomal pathway. The important biological processes involved in skeletal muscle fibrosis include intermuscular connective tissue thickening caused by transforming growth factor-β1 and an anaerobic environment within the skeletal muscle leading to the induction of hypoxia-inducible factor-1α. This article reviews the progress made in understanding the pathological processes involved in immobilization-induced muscle contracture and the currently available treatments. Understanding the mechanisms involved in immobilization-induced contracture of muscle tissue should facilitate the development of more effective treatment measures for the different mechanisms in the future. Keywords: Immobilization-induced joint contracture, Disuse skeletal muscle atrophy, Skeletal muscle fibrosis, Treatment |
| اللغة: | English |
| تدمد: | 1008-1275 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1349039fe5392ab545563f613805d386Test http://www.sciencedirect.com/science/article/pii/S1008127518302967Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....1349039fe5392ab545563f613805d386 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10081275 |
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