Protective effects of taxifolin on pazopanib-induced liver toxicity: an experimental rat model
| العنوان: | Protective effects of taxifolin on pazopanib-induced liver toxicity: an experimental rat model |
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| المؤلفون: | Renad Mammadov, Muhammet Ozer, Bahadir Suleyman, Abdulkadir Coban, Halis Suleyman, Sahin Lacin, Mustafa Özkaraca, Ali Veysel Kara, Fatih Ozcicek, Baran Akagunduz |
| المصدر: | Experimental Animals |
| بيانات النشر: | Japanese Association for Laboratory Animal Science, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Male, Indazoles, Necrosis, Original, experimental models, Pharmacology, Protective Agents, medicine.disease_cause, General Biochemistry, Genetics and Molecular Biology, Hydropic degeneration, taxifolin, Pazopanib, chemistry.chemical_compound, Lactate dehydrogenase, pazopanib, medicine, Animals, oxidative stress, Taxifolin, Rats, Wistar, Sulfonamides, General Veterinary, Stomach, General Medicine, Malondialdehyde, medicine.disease, liver toxicity, Rats, Pyrimidines, medicine.anatomical_structure, Liver, chemistry, Quercetin, Animal Science and Zoology, Chemical and Drug Induced Liver Injury, medicine.symptom, Oxidative stress, medicine.drug |
| الوصف: | Pazopanib is a tyrosine kinase inhibitor that is generally used for the treatment of metastatic renal cell cancer and advanced soft tissue sarcoma. It can cause various degrees of hepatotoxicity. Our study aimed to investigate the effect of taxifolin on pazopanib-induced liver toxicity. A total of 18 rats were divided into three groups: the pazopanib (PP), pazopanib plus taxifolin (TPP), and control (C) group. Taxifolin was administered to the TPP (n=6) group with a dose of 50 mg/kg. Distilled water was orally admnistered to the C (n=6) and PP (n=6) groups as a solvent. Subsequently, pazopanib 200 mg/kg was administered to the TPP and PP groups via the stomach. This procedure was repeated once a day for four weeks. Then, all rats were sacrificed, and their livers were removed. Malondialdehyde (MDA), total glutathione (tGSH), total oxidant status (TOS), and total antioxidant status (TAS) levels were evaluated. MDA and TOS levels were higher in the PP group compared with the levels of the other parameters (P |
| تدمد: | 1881-7122 1341-1357 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::132fa6592797cfb0705b3d5e96453b37Test https://doi.org/10.1538/expanim.20-0103Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....132fa6592797cfb0705b3d5e96453b37 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 18817122 13411357 |
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