Seroreactivity to a Large Panel of Field-Derived Plasmodium falciparum Apical Membrane Antigen 1 and Merozoite Surface Protein 1 Variants Reflects Seasonal and Lifetime Acquired Responses to Malaria
| العنوان: | Seroreactivity to a Large Panel of Field-Derived Plasmodium falciparum Apical Membrane Antigen 1 and Merozoite Surface Protein 1 Variants Reflects Seasonal and Lifetime Acquired Responses to Malaria |
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| المؤلفون: | Algis Jasinskas, Matthew B. Laurens, Rie Nakajima-Sasaki, Christopher V. Plowe, Jeff Skinner, Bourema Kouriba, Andrea A. Berry, Philip L. Felgner, Mahamadou A. Thera, Ogobara K. Doumbo, Jason A. Bailey, Drissa Coulibaly, Shannon Takala-Harrison, Kirsten E. Lyke, Jozelyn Pablo, Amadou Niangaly, Mark A. Travassos, Amed Ouattara |
| المصدر: | The American Journal of Tropical Medicine and Hygiene. 92:9-12 |
| بيانات النشر: | American Society of Tropical Medicine and Hygiene, 2015. |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | Adult, Microarray, Plasmodium falciparum, Protozoan Proteins, Antigens, Protozoan, Biology, Antigen, Virology, parasitic diseases, medicine, Animals, Humans, Malaria, Falciparum, Apical membrane antigen 1, Child, Merozoite Surface Protein 1, Malaria vaccine, Membrane Proteins, biology.organism_classification, medicine.disease, Editorial, Infectious Diseases, Membrane protein, Immunology, Protein microarray, Parasitology, Seasons, Malaria |
| الوصف: | Parasite antigen diversity poses an obstacle to developing an effective malaria vaccine. A protein microarray containing Plasmodium falciparum apical membrane antigen 1 (AMA1, n = 57) and merozoite surface protein 1 19-kD (MSP119, n = 10) variants prevalent at a malaria vaccine testing site in Bandiagara, Mali, was used to assess changes in seroreactivity caused by seasonal and lifetime exposure to malaria. Malian adults had significantly higher magnitude and breadth of seroreactivity to variants of both antigens than did Malian children. Seroreactivity increased over the course of the malaria season in children and adults, but the difference was more dramatic in children. These results help to validate diversity-covering protein microarrays as a promising tool for measuring the breadth of antibody responses to highly variant proteins, and demonstrate the potential of this new tool to help guide the development of malaria vaccines with strain-transcending efficacy. |
| تدمد: | 1476-1645 0002-9637 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12e04104a180e41a6d851b18969ca8f9Test https://doi.org/10.4269/ajtmh.14-0140Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....12e04104a180e41a6d851b18969ca8f9 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14761645 00029637 |
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