Autoantibodies to N-terminally truncated GAD improve clinical phenotyping of individuals with adult-onset diabetes:Action LADA 12
| العنوان: | Autoantibodies to N-terminally truncated GAD improve clinical phenotyping of individuals with adult-onset diabetes:Action LADA 12 |
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| المؤلفون: | Mohammed I. Hawa, R. David Leslie, Vito Lampasona, Alistair J K Williams, Anette-G. Ziegler, Stephanie Krause, Samuel T. Jerram, Peter Achenbach, Ezio Bonifacio |
| المصدر: | Achenbach, P, Hawa, M I, Krause, S, Lampasona, V, Jerram, S T, Williams, A J K, Bonifacio, E, Ziegler, A G, Leslie, R D 2018, ' Autoantibodies to N-terminally truncated GAD improve clinical phenotyping of individuals with adult-onset diabetes : Action LADA 12 ', Diabetologia, vol. 61, no. 7, pp. 1644-1649 . https://doi.org/10.1007/s00125-018-4605-3Test Diabetologia Diabetologia 61, 1644-1649 (2018) |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Adult, Male, Patients, Cross-sectional study, Short Communication, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, 030209 endocrinology & metabolism, Type 2 diabetes, 030204 cardiovascular system & hematology, LADA, 03 medical and health sciences, 0302 clinical medicine, Predictive Value of Tests, Diabetes mellitus, Clinical phenotype, Internal Medicine, medicine, Humans, Hypoglycemic Agents, Insulin, Age of Onset, Aged, Autoantibodies, Type 1 diabetes, Glutamate Decarboxylase, business.industry, GAD, Autoantibody, Adult-onset diabetes, Middle Aged, medicine.disease, Phenotype, Peptide Fragments, ddc, Cross-Sectional Studies, Diabetes Mellitus, Type 1, Immunology, Female, Adult-onset Diabetes, Autoimmune, Clinical Phenotype, Gad, Lada, N-terminally Truncated Gad65, Type 1 Diabetes, Age of onset, business, N-terminally truncated GAD65, Biomarkers |
| الوصف: | Aims/hypothesis Adult-onset type 1 diabetes, in which the 65 kDa isoform of GAD (GAD65) is a major autoantigen, has a broad clinical phenotype encompassing variable need for insulin therapy. This study aimed to evaluate whether autoantibodies against N-terminally truncated GAD65 more closely defined a type 1 diabetes phenotype associated with insulin therapy. Methods Of 1114 participants with adult-onset diabetes from the Action LADA (latent autoimmune diabetes in adults) study with sufficient sera, we selected those designated type 1 (n = 511) or type 2 diabetes (n = 603) and retested the samples in radiobinding assays for human full-length GAD65 autoantibodies (f-GADA) and N-terminally truncated (amino acids 96–585) GAD65 autoantibodies (t-GADA). Individuals’ clinical phenotypes were analysed according to antibody binding patterns. Results Overall, 478 individuals were f-GADA-positive, 431 were t-GADA-positive and 628 were negative in both assays. Risk of insulin treatment was augmented in t-GADA-positive individuals (OR 4.69 [95% CI 3.57, 6.17]) compared with f-GADA-positive individuals (OR 3.86 [95% CI 2.95, 5.06]), irrespective of diabetes duration. Of 55 individuals who were f-GADA-positive but t-GADA-negative, i.e. with antibody binding restricted to the N-terminus of GAD65, the phenotype was similar to type 2 diabetes with low risk of progression to insulin treatment. Compared with these individuals with N-terminal GAD65-restricted GADA, t-GADA-positive individuals were younger at diagnosis (p = 0.005), leaner (p |
| وصف الملف: | application/pdf |
| اللغة: | English |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12b7903e905ee158585adad3646e41a0Test https://research-information.bris.ac.uk/ws/files/163728264/Achenbach2018_Article_AutoantibodiesToN_terminallyTr.pdfTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....12b7903e905ee158585adad3646e41a0 |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |