Genetics and antiepileptic mood stabilizer treatment response in bipolar disorder: what do we know?
| العنوان: | Genetics and antiepileptic mood stabilizer treatment response in bipolar disorder: what do we know? |
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| المؤلفون: | Richard M. Weinshilboum, Mark A. Frye, Ada Man Choi Ho, Joanna M. Biernacka |
| المصدر: | Pharmacogenomics. 22:913-925 |
| بيانات النشر: | Future Medicine Ltd, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Bipolar Disorder, medicine.drug_class, Lamotrigine, Bioinformatics, Antimanic Agents, Genetics, medicine, Humans, Bipolar disorder, Pharmacology, Valproic Acid, Mood Disorders, business.industry, Mood stabilizer, Carbamazepine, Precision medicine, medicine.disease, Treatment Outcome, Mood, Pharmacogenomics, Molecular Medicine, Anticonvulsants, business, Antipsychotic Agents, medicine.drug |
| الوصف: | Antiepileptic mood stabilizers (AED-MS) are often used to treat bipolar disorder (BD). Similar to other mood disorder medications, AED-MS treatment response varies between patients. Identification of biomarkers associated with treatment response may ultimately help with the delivery of individualized treatment and lead to improved treatment efficacy. Here, we conducted a narrative review of the current knowledge of the pharmacogenomics of AED-MS (valproic acid, lamotrigine and carbamazepine) treatment response in BD, including genetic contributions to AED-MS pharmacokinetics. Genes involved in neurotransmitter systems and drug transport have been shown to be associated with AED-MS treatment response. As more studies are conducted, and experimental and analytical methods advance, knowledge of AED-MS pharmacogenomics is expected to grow and contribute to precision medicine in BD. |
| تدمد: | 1744-8042 1462-2416 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11e6b2506f04461c08e2c7ecd724d941Test https://doi.org/10.2217/pgs-2021-0041Test |
| رقم الانضمام: | edsair.doi.dedup.....11e6b2506f04461c08e2c7ecd724d941 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17448042 14622416 |
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