Characteristics and Outcomes of HCV Genotype-1-Infected Patients Treated with Peginterferon and Ribavirin Combination Therapy with Discordant HCV Responses 4 and 12 Weeks after Starting Therapy
| العنوان: | Characteristics and Outcomes of HCV Genotype-1-Infected Patients Treated with Peginterferon and Ribavirin Combination Therapy with Discordant HCV Responses 4 and 12 Weeks after Starting Therapy |
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| المؤلفون: | Michio Sata, Tatsuya Ide, Hiroyuki Ginba, Takashi Kumada, Koichi Takaguchi, Namiki Izumi, Kazuhiro Matsuyama, Noritomo Shimada, Hidenori Toyoda |
| المصدر: | Intervirology. 57:289-296 |
| بيانات النشر: | S. Karger AG, 2014. |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Time Factors, Genotype, Combination therapy, Treatment outcome, Hepacivirus, Antiviral Agents, Gastroenterology, Virus, chemistry.chemical_compound, Hcv genotype 1, Chronic hepatitis, Virology, Internal medicine, Ribavirin, medicine, Humans, Aged, business.industry, Interferon-alpha, virus diseases, Alanine Transaminase, Hepatitis C, Chronic, Middle Aged, Viral Load, digestive system diseases, Treatment Outcome, Infectious Diseases, chemistry, Virologic response, RNA, Viral, Female, business |
| الوصف: | Objective: Some patients with chronic hepatitis C virus (HCV) infection fail to achieve complete early virologic response (EVR) despite a marked decrease in HCV RNA at 4 weeks. We investigated the characteristics and final treatment outcomes of this patient subpopulation. Methods: A total of 516 patients with HCV genotype 1 were enrolled. Background characteristics and final outcomes were compared between patients who achieved complete EVR and those who did not among patients whose HCV RNA levels decreased 3.0 log10 or more at 4 weeks. Results: 78 of 334 patients (23.4%) with a ≥3.0 log10 reduction in HCV RNA levels at 4 weeks failed to achieve complete EVR. Female sex, higher pretreatment HCV RNA levels and lower baseline alanine aminotransferase (ALT) activity were independently associated with failure of complete EVR. The rate of sustained virologic response (SVR) in patients without complete EVR was 47.4%, significantly lower than that in patients with complete EVR (89.7%, p < 0.0001). Conclusions: Female patients, patients with higher pretreatment HCV RNA levels and patients with lower baseline ALT have a high likelihood of failure of complete EVR even when they had a ≥3 log10 reduction of HCV RNA at 4 weeks, resulting in a significantly lower SVR rate. |
| تدمد: | 1423-0100 0300-5526 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11911f20ac6b95ab8de8feca291f94a8Test https://doi.org/10.1159/000362721Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....11911f20ac6b95ab8de8feca291f94a8 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14230100 03005526 |
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