A therapeutic oxygen carrier isolated from Arenicola marina decreases amanitin-induced hepatotoxicity
| العنوان: | A therapeutic oxygen carrier isolated from Arenicola marina decreases amanitin-induced hepatotoxicity |
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| المؤلفون: | Franck Zal, Catherine Ribault, Brendan Le Daré, Vincent Lagente, Eric Delpy, Thomas Gicquel, Pierre-Jean Ferron, Nessrine Bellamri |
| المساهمون: | Nutrition, Métabolismes et Cancer (NuMeCan), Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), CHU Pontchaillou [Rennes], HEMARINA SA, This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors., Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES), Jonchère, Laurent |
| المصدر: | Toxicon Toxicon, 2021, 200, pp.87-91. ⟨10.1016/j.toxicon.2021.07.004⟩ Toxicon, Elsevier, 2021, 200, pp.87-91. ⟨10.1016/j.toxicon.2021.07.004⟩ |
| بيانات النشر: | HAL CCSD, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | endocrine system, Amanitins, animal structures, [SDV]Life Sciences [q-bio], chemistry.chemical_element, Toxicology, Oxygen, Marine worm, 03 medical and health sciences, Hemoglobins, Extracellular, medicine, polycyclic compounds, Humans, Hepatocyte, Oxygen carrier, 030304 developmental biology, Amanitin, 0303 health sciences, biology, Bicyclic molecule, 030302 biochemistry & molecular biology, Hepatotoxicity, biology.organism_classification, 3. Good health, [SDV] Life Sciences [q-bio], medicine.anatomical_structure, chemistry, Biochemistry, Arenicola, Hemoglobin, Chemical and Drug Induced Liver Injury, M101 |
| الوصف: | International audience; The amanitins (namely α- and β-amanitin) contained in certain mushrooms are bicyclic octapeptides that, when ingested, are responsible for potentially lethal hepatotoxicity. M101 is an extracellular hemoglobin extracted from the marine worm Arenicola marina. It has intrinsic Cu/Zn-SOD-like activity and is currently used as an oxygen carrier in organ preservation solutions. Our present results suggest that M101 might be effective in reducing amanitin-induced hepatotoxicity and may have potential for therapeutic development. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 0041-0101 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::116666dc9c5a531add91f6791f531c8aTest https://hal.science/hal-03334103Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....116666dc9c5a531add91f6791f531c8a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 00410101 |
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