Uniting the neurodevelopmental and immunological hypotheses: Neuregulin 1 receptor ErbB and Toll-like receptor activation in first-episode schizophrenia
| العنوان: | Uniting the neurodevelopmental and immunological hypotheses: Neuregulin 1 receptor ErbB and Toll-like receptor activation in first-episode schizophrenia |
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| المؤلفون: | Szabolcs Kéri, Oguz Kelemen, Csilla Szabó |
| المصدر: | Scientific Reports, Vol 7, Iss 1, Pp 1-8 (2017) Scientific Reports |
| بيانات النشر: | Nature Portfolio, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | Adult, Male, 0301 basic medicine, Neuregulin-1, medicine.medical_treatment, Science, Stimulation, Models, Biological, Fluorescence, 03 medical and health sciences, ErbB Receptors, 0302 clinical medicine, ErbB, mental disorders, medicine, Humans, Neuregulin 1, Receptor, ERBB4, Multidisciplinary, biology, business.industry, Toll-Like Receptors, Brain, Confounding Factors, Epidemiologic, medicine.disease, 030104 developmental biology, Cytokine, Schizophrenia, Immunology, biology.protein, Cytokines, Medicine, Female, Erratum, business, 030217 neurology & neurosurgery |
| الوصف: | Current pathophysiological models of schizophrenia focus on neurodevelopmental and immunological mechanisms. We investigated a molecular pathway traditionally linked to the neurodevelopmental hypothesis (neuregulin 1 - ErbB), and pathogen-associated pattern recognition receptors associated with the immune hypothesis (Toll-like receptors, TLRs). We recruited 42 first-episode, drug-naïve patients with schizophrenia and 42 matched healthy control subjects. In monocytes TLR4/TLR5 and ErbB expressions were measured with flow-cytometry. Pro-inflammatory cytokines (IL-1β, IL-6, and TNF-α) and the anti-inflammatory cytokine IL-10 were determined following the stimulation of TLR4/TLR5 and ErbB. Results revealed increased TLR4/TLR5 and decreased ErbB4 expression in schizophrenia relative to the control subjects. The expression of ErbB2 and ErbB3 receptors was unaltered in schizophrenia. TLR4 stimulation resulted in lower pro-inflammatory cytokine production in schizophrenia compared to the control levels, whereas the stimulation of ErbB by neuregulin 1 led to higher pro-inflammatory cytokine levels in patients with schizophrenia relative to the control group. In healthy controls, ErbB activation was associated with a marked production of IL-10, which was dampened in schizophrenia. These results indicate that the stimulation of TLR4 and ErbB induces opposite pro-inflammatory cytokine responses in schizophrenia. |
| اللغة: | English |
| تدمد: | 2045-2322 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::115d43a4bb9b2bda5a653f64aee1eb1bTest https://doaj.org/article/b5b6deeb7cd64c61b5a3fe8336699834Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....115d43a4bb9b2bda5a653f64aee1eb1b |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20452322 |
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