Integrated gut virome and bacteriome dynamics in COVID-19 patients
| العنوان: | Integrated gut virome and bacteriome dynamics in COVID-19 patients |
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| المؤلفون: | Cheng Wang, Ning Zhang, Penghui Yang, Changqing Bai, Jiabao Cao, Linxiang Yu, Yuqing Zhang, Jin Yan, Guanglin Lei, Yi Shi, Yuhuan Gong, Na Zhao, Yuhai Bi, Jingjing Lu, Zhu Chen, Fanping Meng, Lianpan Dai, Jun Wang, Shaogeng Zhang, Kun Xu |
| المصدر: | Gut Microbes article-version (VoR) Version of Record Gut Microbes, Vol 13, Iss 1 (2021) |
| بيانات النشر: | Taylor & Francis, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | 0301 basic medicine, Microbiology (medical), Adult, Male, China, Adolescent, RC799-869, Genome, Viral, Biology, Microbiology, Virus, 03 medical and health sciences, Mice, 0302 clinical medicine, Immune system, medicine, Animals, Humans, Human virome, Microbiome, bacteriome, Aged, Aged, 80 and over, Gastrointestinal tract, virome, Gastrointestinal Microbiome, Gastroenterology, COVID-19, Bacteriome, dysbiosis, Diseases of the digestive system. Gastroenterology, Middle Aged, medicine.disease, Anti-Bacterial Agents, Mice, Inbred C57BL, Disease Models, Animal, MicroRNAs, 030104 developmental biology, Infectious Diseases, Case-Control Studies, Immunology, genetic mutation, 030211 gastroenterology & hepatology, Female, Transcriptome, Dysbiosis, Research Article, Research Paper |
| الوصف: | SARS-CoV-2 is the cause of the current global pandemic of COVID-19; this virus infects multiple organs, such as the lungs and gastrointestinal tract. The microbiome in these organs, including the bacteriome and virome, responds to infection and might also influence disease progression and treatment outcome. In a cohort of 13 COVID-19 patients in Beijing, China, we observed that the gut virome and bacteriome in the COVID-19 patients were notably different from those of five healthy controls. We identified a bacterial dysbiosis signature by observing reduced diversity and viral shifts in patients, and among the patients, the bacterial/viral compositions were different between patients of different severities, although these differences are not entirely distinguishable from the effect of antibiotics. Severe cases of COVID-19 exhibited a greater abundance of opportunistic pathogens but were depleted for butyrate-producing groups of bacteria compared with mild to moderate cases. We replicated our findings in a mouse COVID-19 model, confirmed virome differences and bacteriome dysbiosis due to SARS-CoV-2 infection, and observed that immune/infection-related genes were differentially expressed in gut epithelial cells during infection, possibly explaining the virome and bacteriome dynamics. Our results suggest that the components of the microbiome, including the bacteriome and virome, are affected by SARS-CoV-2 infections, while their compositional signatures could reflect or even contribute to disease severity and recovery processes. |
| اللغة: | English |
| تدمد: | 1949-0984 1949-0976 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1149f8d0b1e518acc9fd013ba768d8cdTest http://europepmc.org/articles/PMC7946006Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....1149f8d0b1e518acc9fd013ba768d8cd |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19490984 19490976 |
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