Long non-coding RNA IGF2-AS represses breast cancer tumorigenesis by epigenetically regulating IGF2
| العنوان: | Long non-coding RNA IGF2-AS represses breast cancer tumorigenesis by epigenetically regulating IGF2 |
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| المؤلفون: | Yanan Zhang, Yanzhi Xu, Jianming Zhang, Yan Jiang, Hui He, Min Lin, Zhijin Ma, Xuemei Zhang, Fei Li, Tao Chen, Hanbing Yan |
| المصدر: | Exp Biol Med (Maywood) |
| بيانات النشر: | SAGE Publications, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Adult, DNA (Cytosine-5-)-Methyltransferase 1, animal structures, endocrine system diseases, Carcinogenesis, Down-Regulation, Mice, Nude, Apoptosis, Breast Neoplasms, Endogeny, Biology, medicine.disease_cause, General Biochemistry, Genetics and Molecular Biology, Epigenesis, Genetic, Phosphatidylinositol 3-Kinases, Breast cancer, Insulin-Like Growth Factor II, Cell Line, Tumor, medicine, Animals, Humans, Promoter Regions, Genetic, Original Research, Cell Proliferation, TOR Serine-Threonine Kinases, Proteins, Middle Aged, medicine.disease, female genital diseases and pregnancy complications, Long non-coding RNA, Gene Expression Regulation, Neoplastic, Cancer research, Female, Proto-Oncogene Proteins c-akt, Function (biology), Protein Binding, Signal Transduction |
| الوصف: | Long non-coding RNAs are a kind of endogenous ncRNAs with a length of more than 200 bp. Accumulating evidence suggests that long non-coding RNAs function as pivotal regulators in tumorigenesis and progression. However, their biological roles in breast cancer remain largely unknown. Here, we found that IGF2 antisense RNA (IGF2-AS) was significantly decreased in breast cancer tissues, cell lines, and plasma. Patients with low IGF2-AS were more likely to develop larger tumor size and later clinical stage. Overexpression of IGF2-AS evidently inhibited the proliferation and induced apoptosis of MCF-7 and T47D cells in vitro, as well as retarded tumor growth in vivo. Further investigation revealed that IGF2-AS inhibited the expression of its sense-cognate gene IGF2 in an epigenetic DNMT1-dependent manner, resulting in the inactivation of downstream oncogenic PI3K/AKT/mTOR signaling pathway. Enforced expression of IGF2 could significantly block the tumor inhibitory effect of IGF2-AS. Importantly, we found that IGF2-AS could be used as an effective biomarker for breast cancer diagnosis and prognosis. Taken together, our study indicates that IGF2-AS is a tumor suppressor in breast cancer, restoration of IGF2-AS may be a promising treatment for this fatal disease. |
| تدمد: | 1535-3699 1535-3702 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11048f33e670b798c0088bfc0a73f8a4Test https://doi.org/10.1177/1535370220966253Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....11048f33e670b798c0088bfc0a73f8a4 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15353699 15353702 |
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