Bisphenol S instead of Bisphenol A: Toxicokinetic investigations in the ovine materno-feto-placental unit
| العنوان: | Bisphenol S instead of Bisphenol A: Toxicokinetic investigations in the ovine materno-feto-placental unit |
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| المؤلفون: | Hanna Mila, Nicole Picard-Hagen, Marlène Z. Lacroix, Pierre-Louis Toutain, Glenn Gauderat, Véronique Gayrard, Flore C. Grandin |
| المساهمون: | ToxAlim (ToxAlim), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Ecole d'Ingénieurs de Purpan (INPT - EI Purpan), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Recherche Agronomique (INRA), Innovations Thérapeutiques et Résistances (InTheRes), Institut National de la Recherche Agronomique (INRA)-Ecole Nationale Vétérinaire de Toulouse (ENVT), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées, Exposition, Perturbation Endocrino-métabolique et Reproduction (ToxAlim-EXPER), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Recherche Agronomique (INRA)-Université Toulouse III - Paul Sabatier (UT3) |
| المصدر: | Environment International, Vol 120, Iss, Pp 584-592 (2018) Environment International Environment International, Elsevier, 2018, 120, pp.584-592. ⟨10.1016/j.envint.2018.08.019⟩ |
| بيانات النشر: | Elsevier, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | 0301 basic medicine, Male, Bisphenol A, Bisphenol S, [SDV]Life Sciences [q-bio], Placenta, Urine, 010501 environmental sciences, Endocrine Disruptors, Fetal exposure, urologic and male genital diseases, 01 natural sciences, chemistry.chemical_compound, Bisphenol S Glucuronide, Pregnancy, Bisphenol A analogue, Sulfones, Maternal-Fetal Exchange, lcsh:Environmental sciences, General Environmental Science, lcsh:GE1-350, Compartment (chemistry), Toxicokinetic, 3. Good health, Toxicokinetics, embryonic structures, Female, hormones, hormone substitutes, and hormone antagonists, endocrine system, Andrology, 03 medical and health sciences, Fetus, Glucuronides, Phenols, medicine, Animals, Humans, Benzhydryl Compounds, 0105 earth and related environmental sciences, Sheep, business.industry, medicine.disease, 030104 developmental biology, chemistry, business |
| الوصف: | Bisphenol S (BPS) is widely used as a substitute for Bisphenol A in consumer products. Despite its potential endocrine-disrupting effects and widespread exposure, toxicokinetic data, particularly during the critical period of pregnancy, are not available for BPS. The objectives of our study were to evaluate the mechanisms determining fetal exposure to BPS and to BPS glucuronide (BPSG) and to compare them with those prevailing for BPA.The disposition of BPS and BPSG was evaluated in the materno-fetal unit of the catheterized pregnant ewe model, following intravenous administrations of BPS and BPSG to mothers and their fetuses. In a second experiment, the rate of BPS accumulation in the fetal compartment was determined under steady-state conditions after repeated intravenous BPS administrations to the mother.In the maternal compartment, BPS was mainly metabolized into BPSG and totally eliminated in urine. Only 0.40% of the maternal dose was transferred to the fetus. However, once in the fetal compartment, 26% of the fetal dose was rapidly eliminated through placental transfer, while 46% of BPS was metabolized into BPSG which remained trapped in the fetal compartment. Thus, the elimination of BPSG from the fetal compartment required its back-conversion into bioactive BPS, leading to an 87% enhancement of the fetal BPS exposure.Our findings demonstrate that, despite the low materno-fetal placental transfer of BPS, this substitute for BPA is able to accumulate in the fetal compartment after repeated maternal exposure, leading to chronic fetal exposure to BPS in a range of concentrations similar to those of BPA. Keywords: Bisphenol S, Bisphenol S Glucuronide, Toxicokinetic, Fetal exposure, Bisphenol A analogue |
| اللغة: | English |
| تدمد: | 0160-4120 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::101d7eb9f4569d63dc0a896ff52d5fedTest http://www.sciencedirect.com/science/article/pii/S0160412018308353Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....101d7eb9f4569d63dc0a896ff52d5fed |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 01604120 |
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