Predictors of bone fractures in a single-centre cohort of hemodialysis patients: a 2-year follow-up study
| العنوان: | Predictors of bone fractures in a single-centre cohort of hemodialysis patients: a 2-year follow-up study |
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| المؤلفون: | Ivan Rychlik, Alena Fialová, Jana Verešová, Petr Kasalický, Ludmila Brunerová, Jana Potockova, Renata Lažanská |
| المصدر: | International Urology and Nephrology. 50:1721-1728 |
| بيانات النشر: | Springer Science and Business Media LLC, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Male, Nephrology, medicine.medical_specialty, FRAX, Urology, medicine.medical_treatment, 030232 urology & nephrology, 030209 endocrinology & metabolism, Hemodiafiltration, Body Mass Index, Bone remodeling, Fractures, Bone, 03 medical and health sciences, 0302 clinical medicine, Trabecular bone score, Bone Density, Risk Factors, Internal medicine, Vitamin D and neurology, medicine, Humans, Vitamin D, Aged, Aged, 80 and over, business.industry, Escherichia coli Proteins, Middle Aged, medicine.disease, Parathyroid Hormone, Cohort, Kidney Failure, Chronic, Female, Hemodialysis, business, Acyltransferases, Follow-Up Studies, Kidney disease |
| الوصف: | Bone involvement represents one of the complications of end-stage chronic kidney disease, with fractures being its major risk. The aim of our study was to assess the frequency and predictors of low-trauma fractures in a cohort of maintenance hemodialysis patients followed-up on for 2 years. 59 patients (67.6 ± 13.1 years, 43 males) treated with hemodiafiltration underwent initially laboratory (markers of calcium–phosphate metabolism and bone turnover markers) and densitometry examination with TBS assessment (Lunar Prodigy, TBS software 2.1.2). During 24-month follow-up, the frequency of low-trauma fractures was assessed and possible predictors of increased fracture risk were identified using product–moment correlation matrices. Altogether 7 (11.9%) low-trauma fractures were observed. In the whole group, age (P = 0.047), T-score in proximal femur (P = 0.04), low vitamin D, low BMI (P = 0.03 for both), and higher FRAX for major osteoporotic fracture (P = 0.01) were connected with fractures, but in multi-variate analysis only BMI remained significantly negatively associated with fractures (P = 0.047). TBS and bone turnover markers failed to predict fractures. However, women with fractures had significantly lower serum phosphate (P = 0.03) and higher parathyroid hormone (P = 0.04). Parameters of hip structure analysis significantly correlated with FRAX, but not with fractures. In a group of hemodialysis patients from one centre, T-score in proximal femur, low vitamin D, low BMI, and high FRAX for major osteoporotic fracture were associated with low-trauma fractures, however, in multi-variate analysis only low BMI remained a significant predictor of fracture risk. |
| تدمد: | 1573-2584 0301-1623 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f8e3a5c2e4024fe61ef601d838ed7e4Test https://doi.org/10.1007/s11255-018-1958-yTest |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....0f8e3a5c2e4024fe61ef601d838ed7e4 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15732584 03011623 |
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