Metabolic Syndrome and Colorectal Cancer Risk: Results of Propensity Score-Based Analyses in a Community-Based Cohort Study
| العنوان: | Metabolic Syndrome and Colorectal Cancer Risk: Results of Propensity Score-Based Analyses in a Community-Based Cohort Study |
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| المؤلفون: | Byung-Mi Kim, Eun-Jung Park, Min Kyung Lim, Jin-Kyoung Oh, Jinsun Kim, Eun Young Park |
| المصدر: | International Journal of Environmental Research and Public Health International Journal of Environmental Research and Public Health, Vol 17, Iss 8687, p 8687 (2020) Volume 17 Issue 22 |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, Colorectal cancer, Health, Toxicology and Mutagenesis, lcsh:Medicine, colorectal cancer, Article, Cohort Studies, 03 medical and health sciences, 0302 clinical medicine, Risk Factors, Internal medicine, medicine, Humans, 030212 general & internal medicine, Stage (cooking), Propensity Score, Aged, Metabolic Syndrome, business.industry, lcsh:R, Public Health, Environmental and Occupational Health, Cancer, cohort, Middle Aged, medicine.disease, Confidence interval, 030220 oncology & carcinogenesis, propensity score methods, Propensity score matching, Cohort, Colonic Neoplasms, Female, Metabolic syndrome, business, Colorectal Neoplasms, Cohort study |
| الوصف: | Background: This study aimed to determine the effects of metabolic syndrome (MetS) on colorectal cancer (CRC) using propensity score (PS) methods. Methods: The study subjects were 2417 men and 4568 women from the Korean National Cancer Center (KNCC) Community Cohort enrolled between 2003 and 2010. Odds risks (ORs) and 95% confidence intervals (CIs) using PS matching analysis, regression models adjusted by the PS or stratified into five strata according to PS, and PS weighting methods were calculated. Results: In women, MetS and abnormally high triglyceride (TG) levels were associated with CRC risk using the PS matching analysis (ORs, for MetS, 2.19 (95% CI, 1.10&ndash 4.33) for abnormal TG levels, 2.08 (95% CI, 1.07&ndash 4.02)). However, there were no significant associations between MetS and TG levels and CRC risk in men. Conclusions: Our study might provide additional evidence that deteriorated metabolic profiles increase the risk of CRC in women rather than men. Thus, this may have an important role in effective population-level interventions for deteriorated metabolic profiles at an early stage. |
| وصف الملف: | application/pdf |
| تدمد: | 1660-4601 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f2660086deb6e24180a8bdcfcf1c607Test https://pubmed.ncbi.nlm.nih.gov/33238496Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....0f2660086deb6e24180a8bdcfcf1c607 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16604601 |
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