Metabotropic glutamate receptor 1 is associated with unfavorable prognosis in ER-negative and triple-negative breast cancer
| العنوان: | Metabotropic glutamate receptor 1 is associated with unfavorable prognosis in ER-negative and triple-negative breast cancer |
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| المؤلفون: | Renée Foekens, Wendy J. C. Prager-van der Smissen, Marcel Smid, Peter A. E. Sillevis Smitt, A. Mieke Timmermans, Carolien H.M. van Deurzen, Esther Hulsenboom, Anita M. A. C. Trapman-Jansen, John W.M. Martens, Martijn M. VanDuijn, Anna E M Bastiaansen, Theo M. Luider |
| المساهمون: | Neurology, Medical Oncology, Pathology |
| المصدر: | Scientific Reports Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020) Scientific Reports, 10(1):22292. Nature Publishing Group |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Oncology, Adult, medicine.medical_specialty, Multivariate analysis, Receptor, ErbB-2, Science, Estrogen receptor, Breast Neoplasms, Triple Negative Breast Neoplasms, Receptors, Metabotropic Glutamate, Disease-Free Survival, Article, Prognostic markers, Breast cancer, SDG 3 - Good Health and Well-being, Internal medicine, medicine, Biomarkers, Tumor, Humans, skin and connective tissue diseases, Triple-negative breast cancer, Retrospective Studies, Cancer, Multidisciplinary, Tissue microarray, business.industry, Retrospective cohort study, Middle Aged, medicine.disease, Prognosis, ER Negative, Gene Expression Regulation, Neoplastic, Receptors, Estrogen, Medicine, Metabotropic glutamate receptor 1, Female, business |
| الوصف: | New therapies are an urgent medical need in all breast cancer subgroups. Metabotropic glutamate receptor 1 (mGluR1) is suggested as a potential new molecular target. We examined the prevalence mGluR1 expression in different clinically relevant breast cancer subgroups and determined its association with prognosis. In this retrospective cohort, 394 consecutive primary breast cancer tissues were incorporated into a tissue microarray and immunohistochemically stained for mGluR1. The prevalence of mGluR1 protein expression in different breast cancer subgroups was evaluated and correlated with metastasis-free survival (MFS) and overall survival (OS). In total, 56% (n = 219) breast cancer tissues had mGluR1 expression. In estrogen receptor (ER)-negative tumors, 31% (n = 18/58) had mGluR1 expression that was significantly associated with MFS (HR 5.00, 95% CI 1.03–24.35, p = 0.046) in multivariate analysis, independently from other prognostic factors. Of the 44 triple-negative breast cancer (TNBC), 25% (n = 11) expressed mGluR1. mGluR1 expression in TNBC was significantly associated with shorter MFS (HR 8.60, 95% CI 1.06–20.39, p = 0.044) and with poor OS (HR 16.07, 95% CI 1.16–223.10, p = 0.039). In conclusion, mGluR1 is frequently expressed in breast cancer. In ER-negative breast cancer and in TNBC mGluR1 protein expression is an unfavorable prognostic marker. This study provides rationale to explore mGluR1 as a novel target for breast cancer treatment, especially for the more aggressive TNBC. |
| وصف الملف: | application/pdf |
| تدمد: | 2045-2322 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f030decbe5b557b3a9887d71dde05dbTest https://pubmed.ncbi.nlm.nih.gov/33339858Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....0f030decbe5b557b3a9887d71dde05db |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20452322 |
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