The PTPN22 C1858T (R620W) functional polymorphism in inflammatory bowel disease
| العنوان: | The PTPN22 C1858T (R620W) functional polymorphism in inflammatory bowel disease |
|---|---|
| المؤلفون: | Aurora Serrano, Mounia Oudghiri, Sellama Nadifi, Mehdi Karkouri, Fatima Zahra Bakhtaoui, Javier Martín, Younes Zaid, Nadia Serbati, Wafaa Badre, Nezha Senhaji |
| المصدر: | BMC Research Notes Digital.CSIC. Repositorio Institucional del CSIC instname BMC Research Notes, Vol 11, Iss 1, Pp 1-6 (2018) |
| بيانات النشر: | BioMed Central, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | 0301 basic medicine, medicine.medical_specialty, IBD, lcsh:Medicine, Disease, Inflammatory bowel disease, Gastroenterology, Polymorphism, Single Nucleotide, General Biochemistry, Genetics and Molecular Biology, PTPN22, Cohort Studies, 03 medical and health sciences, 0302 clinical medicine, UC, Crohn Disease, Internal medicine, Genotype, medicine, Humans, Allele, lcsh:Science (General), lcsh:QH301-705.5, Functional polymorphism, business.industry, lcsh:R, Protein Tyrosine Phosphatase, Non-Receptor Type 22, General Medicine, medicine.disease, Inflammatory Bowel Diseases, Ulcerative colitis, digestive system diseases, CD, Research Note, Morocco, 030104 developmental biology, lcsh:Biology (General), Cohort, Colitis, Ulcerative, business, 030215 immunology, lcsh:Q1-390 |
| الوصف: | [Objective] In view of the discrepant data regarding the association between the protein tyrosine phosphatase non-receptor 22 (PTPN22) rs2476601 (R620W, 1858C→T) polymorphism and susceptibility to autoimmune diseases including inflammatory bowel diseases (IBD), we investigated whether this functional single-nucleotide polymorphism influences IBD risk in a group of Moroccan patients. [Results] This is the first report on the prevalence of PTPN22 (R620W) variant in a Moroccan cohort. No evidence of statistically significant differences was observed when the PTPN22 (R620W) allele and genotype distribution among IBD, Crohn’s disease (CD), ulcerative colitis (UC) patients and healthy controls were compared. The frequency of the variant allele in healthy subjects was 1.77% compared to 2.56% in the IBD patients and 1.85% in CD patients. Furthermore, the frequency of this allele was increased in UC patients compared to controls (4.17% vs. 1.77%, OR = 2.42, 95% CI 0.82–7.08; P = 0.09), but the difference was not statistically significant. Our data suggest a lack of association between PTPN22 R620W variant and IBD susceptibility in Moroccan patients. |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e5d04ffc5e08f1904a3c27909a436e8Test http://hdl.handle.net/10261/171830Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....0e5d04ffc5e08f1904a3c27909a436e8 |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |