Relationship between quality of life and survival in patients with pancreatic and periampullary cancer
| العنوان: | Relationship between quality of life and survival in patients with pancreatic and periampullary cancer |
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| المؤلفون: | I. Quintus Molenaar, Susan van Dieren, Mirjam A. G. Sprangers, Marjolein Y.V. Homs, Casper H.J. van Eijck, Marc G. Besselink, Ignace H. J. T. de Hingh, Johanna W. Wilmink, Lydia G. M. van der Geest, Geert-Jan Creemers, Gijs A. Patijn, Jan-Willem B de Groot, Tara M. Mackay, Lonneke V. van de Poll-Franse, Judith de Vos-Geelen, Bas Groot Koerkamp, Hanneke W. M. van Laarhoven, Evelien J M de Jong, Anouk E J Latenstein, Hjalmar C. van Santvoort |
| المساهمون: | Medical and Clinical Psychology, Surgery, Medical Oncology, Medical Psychology, APH - Mental Health, APH - Personalized Medicine, CCA - Cancer Treatment and Quality of Life, APH - Methodology, Oncology, CCA -Cancer Center Amsterdam, AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, APH - Aging & Later Life, Interne Geneeskunde, MUMC+: MA Medische Oncologie (9), RS: GROW - R3 - Innovative Cancer Diagnostics & Therapy |
| المصدر: | Journal of the National Comprehensive Cancer Network, 18(10), 1354-1363. Cold Spring Publishing LLC Journal of the National Comprehensive Cancer Network, 18(10), 1354-+. Cold Spring Publishing LLC Journal of the National Comprehensive Cancer Network, 18(10), 1354-1363. Harborside Press |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | medicine.medical_specialty, Multivariate analysis, RESECTION, IMPACT, Adenocarcinoma, 03 medical and health sciences, 0302 clinical medicine, Quality of life, SDG 3 - Good Health and Well-being, Internal medicine, Surveys and Questionnaires, medicine, Periampullary cancer, Humans, REPORTED OUTCOMES, Patient Reported Outcome Measures, Prospective Studies, Registries, HEAD, Netherlands, Proportional hazards model, business.industry, STATEMENT, Hazard ratio, QLQ-C30, people.cause_of_death, humanities, Cancer registry, Pancreatic Neoplasms, Survival Rate, TRIALS, Oncology, 030220 oncology & carcinogenesis, Cohort, Quality of Life, 030211 gastroenterology & hepatology, HEALTH, business, people, Cohort study |
| الوصف: | Background: A relationship between quality of life (QoL) and survival has been shown for several types of cancer, mostly in clinical trials with highly selected patient groups. The relationship between QoL and survival for patients with pancreatic or periampullary cancer is unclear. Methods: This study analyzed QoL data from a prospective multicenter patient-reported outcome registry in patients with pancreatic or periampullary carcinoma registered in the nationwide Netherlands Cancer Registry (2015–2018). Baseline and delta QoL, between baseline and 3-month follow-up, were assessed with the Happiness, EORTC Quality of Life Questionnaire-Core 30 (QLQ-C30), and QLQ-PAN26 questionnaires. The relationship between QoL and survival was assessed using Cox regression models, and additional prognostic value of separate items was assessed using Nagelkerke R2 (explained variance). Results: For the baseline and delta analyses, 233 and 148 patients were available, respectively. Most were diagnosed with pancreatic adenocarcinoma (n=194; 83.3%) and had stage III disease (n=77; 33.0%), with a median overall survival of 13.6 months. Multivariate analysis using baseline scores indicated several scales to be of prognostic value for the total cohort (ie, happiness today, role functioning, diarrhea, pancreatic pain, and body image; hazard ratios all PP5% of the additional explained variance and were of added prognostic value. Multivariate analysis using delta QoL revealed that only constipation was of prognostic value for the total cohort, whereas no association with survival was found for subgroups with or without resection. Conclusions: In a multicenter cohort of patients with pancreatic or periampullary carcinoma, QoL scores predicted survival regardless of patient, tumor, and treatment characteristics. QoL scores may thus be used for shared decision-making regarding disease management and treatment choice. |
| اللغة: | English |
| تدمد: | 1540-1405 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e1cecba50c06fdfca2aede68f3d2eefTest https://doi.org/10.6004/jnccn.2020.7579Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....0e1cecba50c06fdfca2aede68f3d2eef |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15401405 |
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