Dosimetric impact of 3D motion-compensated SPECT reconstruction for SIRT planning
| العنوان: | Dosimetric impact of 3D motion-compensated SPECT reconstruction for SIRT planning |
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| المؤلفون: | Laure Vergnaud, Antoine Robert, Thomas Baudier, Sandrine Parisse-Di Martino, Philippe Boissard, Simon Rit, Jean-Noël Badel, David Sarrut |
| المساهمون: | Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé (CREATIS), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Hospices Civils de Lyon (HCL)-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre Léon Bérard [Lyon], Rit, Simon |
| المصدر: | EJNMMI Physics EJNMMI Physics, 2023, 10 (1), pp.8. ⟨10.1186/s40658-023-00525-y⟩ |
| بيانات النشر: | Springer Science and Business Media LLC, 2023. |
| سنة النشر: | 2023 |
| مصطلحات موضوعية: | 99m Tc-MAA, [PHYS.PHYS.PHYS-MED-PH] Physics [physics]/Physics [physics]/Medical Physics [physics.med-ph], Radiation, Breathing motion, Dosimetry, [PHYS.PHYS.PHYS-MED-PH]Physics [physics]/Physics [physics]/Medical Physics [physics.med-ph], Biomedical Engineering, Radiology, Nuclear Medicine and imaging, SPECT/CT, Radioembolization, Instrumentation, 3D compensated reconstruction |
| الوصف: | Background In selective internal radiation therapy, 99mTc SPECT images are used to optimize patient treatment planning, but they are affected by respiratory motion. In this study, we evaluated on patient data the dosimetric impact of motion-compensated SPECT reconstruction on several volumes of interest (VOI), on the tumor-to-normal liver (TN) ratio and on the activity to be injected. Methods Twenty-nine patients with liver cancer or hepatic metastases treated by radioembolization were included in this study. The biodistribution of 90Y is assumed to be the same as that of 99mTc when predictive dosimetry is implemented. A total of 31 99mTc SPECT images were acquired and reconstructed with two methods: conventional OSEM (3D) and motion-compensated OSEM (3Dcomp). Seven VOI (liver, lungs, tumors, perfused liver, hepatic reserve, healthy perfused liver and healthy liver) were delineated on the CT or obtained by thresholding SPECT images followed by Boolean operations. Absorbed doses were calculated for each reconstruction using Monte Carlo simulations. Percentages of dose difference (PDD) between 3Dcomp and 3D reconstructions were estimated as well as the relative differences for TN ratio and activities to be injected. The amplitude of movement was determined with local rigid registration of the liver between the 3Dcomp reconstructions of the extreme phases of breathing. Results The mean amplitude of the liver was 9.5 ± 2.7 mm. Medians of PDD were closed to zero for all VOI except for lungs (6.4%) which means that the motion compensation overestimates the absorbed dose to the lungs compared to the 3D reconstruction. The smallest lesions had higher PDD than the largest ones. Between 3D and 3Dcomp reconstructions, means of differences in lung dose and TN ratio were not statistically significant, but in some cases these differences exceed 1 Gy (4/31) and 8% (2/31). The absolute differences in activity were on average 3.1% ± 5.1% and can reach 22.8%. Conclusion The correction of respiratory motion mainly impacts the lung and tumor doses but only for some patients. The largest dose differences are observed for the smallest lesions. |
| وصف الملف: | application/pdf |
| تدمد: | 2197-7364 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cf1ed10f152489444ed1680fcfbecbeTest https://doi.org/10.1186/s40658-023-00525-yTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....0cf1ed10f152489444ed1680fcfbecbe |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 21977364 |
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