Daily insulin requirement of children and adolescents with type 1 diabetes: effect of age, gender, body mass index and mode of therapy
| العنوان: | Daily insulin requirement of children and adolescents with type 1 diabetes: effect of age, gender, body mass index and mode of therapy |
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| المؤلفون: | Susanna Wiegand, Klemens Raile, Thomas Reinehr, Sabine Hofer, Andrea Näke, Wolfgang Rabl, Reinhard W Holl |
| المصدر: | European Journal of Endocrinology. 158:543-549 |
| بيانات النشر: | Oxford University Press (OUP), 2008. |
| سنة النشر: | 2008 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Adolescent, Health Planning Guidelines, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Drug Administration Schedule, Body Mass Index, Injections, Endocrinology, Insulin resistance, Diabetes mellitus, Internal medicine, medicine, Humans, Insulin, Drug Dosage Calculations, Longitudinal Studies, Child, Pancreatic hormone, Sex Characteristics, Type 1 diabetes, business.industry, Drug Administration Routes, Age Factors, General Medicine, medicine.disease, Diabetes Mellitus, Type 1, El Niño, Child, Preschool, Multivariate Analysis, Female, business, Body mass index, Sex characteristics |
| الوصف: | DesignThe purpose of this study was to generate insulin dose (ID) percentiles for children and adolescents with type 1 diabetes mellitus (DM1) having the opportunity to assess this important parameter in relation to age and sex.MethodsDaily IDs per weight (ID/kg) were recorded in 22 177 patients with DM1 (3–25 years of age, DM1 duration of more than 2 years, 48% female) and ID percentiles (ID-Perc) were created statistically. The ID-Perc were compared between male and female, and between multiple insulin injection therapy (MIT) and continuous s.c. insulin infusion (CSII). A multivariate regression analysis was performed for ID in the third year of DM1 with ID/kg, body weight, age, gender, and insulin delivery regimen as variables.ResultsThe 50th ID-Perc (P50) varied among 0.67 IU/kg (age 3 years), 0.93 IU/kg (13 years), and 0.70 IU/kg (23 years) increasing from early childhood to adolescence and decreasing toward adulthood. Highest P50 ID was found at 12 years in females (0.94 IU/kg) and at 14 years in males (0.92 IU/kg). Using ICT, the ID was significantly higher compared with CSII (P50: 0.94 IU/kg versus 0.79 IU/kg at 13 years). In multivariate regression analysis, ID was significantly (P>0.001) associated with age, gender, and insulin delivery regime.ConclusionThe ID-Perc were significantly different during various periods of childhood and were influenced by gender, body weight, and insulin injection regimes. Therefore, the presented data 1) provide evidence to interpret individual ID in children and adolescents with DM1 and 2) more specifically identify children with unusually high (insulin resistance and non-compliance) or low (MODY and persistent remission) insulin requirement. |
| تدمد: | 1479-683X 0804-4643 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cc1763010d84b3209dc9d8ce6e38bedTest https://doi.org/10.1530/eje-07-0904Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....0cc1763010d84b3209dc9d8ce6e38bed |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1479683X 08044643 |
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