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Co-inoculation of baculovirus and FMDV vaccine in mice, elicits very early protection against foot and mouth disease virus without interfering with long lasting immunity

التفاصيل البيبلوغرافية
العنوان: Co-inoculation of baculovirus and FMDV vaccine in mice, elicits very early protection against foot and mouth disease virus without interfering with long lasting immunity
المؤلفون: Valeria Quattrocchi, Patricia Ines Zamorano, P. Molinari, Oscar Taboga, Cecilia Langellotti, V. Gnazzo
المصدر: Vaccine
سنة النشر: 2013
مصطلحات موضوعية: BACULOVIRUS, animal diseases, medicine.medical_treatment, Viremia, Biology, Antibodies, Viral, FMDV, Ciencias Biológicas, Mice, 03 medical and health sciences, 0302 clinical medicine, Immune system, Antigen, Immunity, medicine, Animals, 030304 developmental biology, Immunity, Cellular, Mice, Inbred BALB C, 0303 health sciences, General Veterinary, General Immunology and Microbiology, Foot-and-mouth disease, Viral Vaccine, Public Health, Environmental and Occupational Health, Viral Vaccines, biochemical phenomena, metabolism, and nutrition, biology.organism_classification, medicine.disease, Virology, 3. Good health, Infectious Diseases, Vaccines, Inactivated, Foot-and-Mouth Disease Virus, Foot-and-Mouth Disease, Immunology, Molecular Medicine, Female, Foot-and-mouth disease virus, Baculoviridae, Virología, Adjuvant, CIENCIAS NATURALES Y EXACTAS, EARLY IMMUNITY, 030215 immunology
الوصف: Baculoviruses (Bvs) potentiate the immune response against soluble antigens. We investigated whether Bv could be used as immunoactivator in foot-and-mouth disease (FMD) vaccines using the BALB/c mouse model. Mice were vaccinated with a single dose of inactivated FMDV (iFMDV), iFMDV. +. Bv, Bv, or culture medium. Humoral and cellular immune responses were higher in animals immunized with iFMDV. +. Bv than in mice vaccinated with iFMDV alone. Animals receiving iFMDV. +. Bv had significantly lower viremia at 2, 4 and 7. dpv, than those immunized with iFMDV alone. In order to prolong the immune response, iFMDV oil vaccine was co-inoculated with Bv. Animals receiving iFMDV oil vaccine. +. Bv were protected two days earlier than those receiving the iFMDV oil vaccine alone. Both formulations protected until 14. dpv, the last day of the experiment.This is the first report in which Bv is used as an adjuvant in a FMDV vaccine. Fil: Quattrocchi, Valeria. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación en Ciencias Veterinarias y Agronómicas. Instituto de Virología; Argentina Fil: Molinari, Maria Paula. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad del Salvador; Argentina Fil: Langellotti, Cecilia Ana. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad del Salvador; Argentina Fil: Gnazzo, Victoria. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad del Salvador; Argentina Fil: Taboga, Oscar Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación en Ciencias Veterinarias y Agronómicas. Instituto de Virología; Argentina Fil: Zamorano, Patricia Ines. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación en Ciencias Veterinarias y Agronómicas. Instituto de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
وصف الملف: application/pdf
اللغة: English
تدمد: 0264-410X
DOI: 10.1016/j.vaccine.2013.03.067
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c9ed49de69417b6c159b234ec394777Test
حقوق: RESTRICTED
رقم الانضمام: edsair.doi.dedup.....0c9ed49de69417b6c159b234ec394777
قاعدة البيانات: OpenAIRE
الوصف
تدمد:0264410X
DOI:10.1016/j.vaccine.2013.03.067