Cell Cycle Genes Are Potential Diagnostic and Prognostic Biomarkers in Hepatocellular Carcinoma
| العنوان: | Cell Cycle Genes Are Potential Diagnostic and Prognostic Biomarkers in Hepatocellular Carcinoma |
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| المؤلفون: | Li Dongen, Yang Liang, Jiang Jianshuai, Chen Qi, Li Jia, Xu LiPing |
| المصدر: | BioMed Research International, Vol 2020 (2020) BioMed Research International |
| بيانات النشر: | Hindawi Limited, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Adult, Male, 0301 basic medicine, Oncology, medicine.medical_specialty, Carcinoma, Hepatocellular, Article Subject, Sensitivity and Specificity, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Biomarkers, Tumor, Carcinoma, medicine, Humans, Survival analysis, Cyclin-dependent kinase 1, General Immunology and Microbiology, business.industry, Liver Neoplasms, Computational Biology, General Medicine, Odds ratio, Middle Aged, Cell cycle, Prognosis, medicine.disease, MAD1L1, Survival Analysis, Cell Cycle Gene, Genes, cdc, 030104 developmental biology, 030220 oncology & carcinogenesis, Hepatocellular carcinoma, Medicine, Female, Corrigendum, business, Research Article |
| الوصف: | Background. The cell cycle pathway genes are comprised of 113 members which are critical to the maintenance of cell cycle and survival of tumor cells. This study was performed to investigate the diagnostic and prognostic values of cell cycle gene expression in hepatocellular carcinoma (HCC) patients. Methods. Clinical features and cell cycle pathway gene expression data were obtained from the Gene Expression Omnibus and The Cancer Genome Atlas databases. Differentially expressed genes (DEGs) were determined by the student t-test between HCC and noncancerous samples. Kaplan-Meier survival, univariate, and multivariate survival analyses and validation analysis were performed to characterize the associations between cell cycle gene expression and patients’ overall survival and recurrence-free survival. Results. 47 and 5 genes were significantly upregulated and downregulated genes in HCC samples, respectively. The high expression of BUB3, CDK1, and CHEK1 was associated with increased mortality (adjusted P value = 0.04, odds ratio (OR): 1.89 (95% confidence interval (CI): 1.04-3.46); adjusted P value = 0.02, OR: 2.06 (95% CI:1.15-3.75); and adjusted P value = 0.04, OR: 1.84 (%95 CI: 1.03-3.32), respectively). The expression of PTTG2 and RAD21 was significantly associated with cancer recurrence (adjusted P value = 0.01, OR: 2.17 (95% CI: 1.24-3.86); adjusted P value = 0.03, OR: 1.88[95% CI:1.08-3.28], respectively), while the low expression of MAD1L1 was associated with cancer recurrence (adjusted P value = 0.03, OR: 0.53 (%95 CI: 0.3-0.93)). Conclusions. The present study demonstrated that BUB3, CDK1, and CHEK1 may serve as a prognostic biomarker for HCC patients. PTTG2, RAD21, and MAD1L1 expression is a major factor affecting the recurrence of HCC patients. |
| وصف الملف: | text/xhtml |
| اللغة: | English |
| تدمد: | 2314-6141 2314-6133 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c56f3a346670c9838c1d048132e0cf3Test https://doaj.org/article/c917705a046448fca760514167130685Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....0c56f3a346670c9838c1d048132e0cf3 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 23146141 23146133 |
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