An elevated pro-inflammatory cytokine response is linked to development of amphotericin B-induced nephrotoxicity
| العنوان: | An elevated pro-inflammatory cytokine response is linked to development of amphotericin B-induced nephrotoxicity |
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| المؤلفون: | Boon Wee Teo, Lay Wai Khin, Bart Jan Kullberg, Bee Choo Tai, Louis Y.A. Chai, Alieke G. Vonk, Raoul Herbrecht, Peter F. Troke, J.P. Donnelly, Haran T. Schlamm, Mihai G. Netea |
| المساهمون: | Medical Microbiology & Infectious Diseases |
| المصدر: | Journal of Antimicrobial Chemotherapy, 68, 7, pp. 1655-9 Journal of Antimicrobial Chemotherapy, 68(7), 1655-1659. Oxford University Press Journal of Antimicrobial Chemotherapy, 68, 1655-9 |
| بيانات النشر: | Oxford University Press, 2013. |
| سنة النشر: | 2013 |
| مصطلحات موضوعية: | Adult, Male, Serum, Microbiology (medical), Invasive mycoses and compromised host Translational research [N4i 2], medicine.medical_specialty, Antifungal Agents, Invasive mycoses and compromised host Infection and autoimmunity [N4i 2], Gastroenterology, Nephrotoxicity, Amphotericin B, Amphotericin B deoxycholate, Internal medicine, medicine, Humans, Pharmacology (medical), Interleukin 6, Aged, Pharmacology, biology, Interleukin-6, business.industry, Interleukin-8, Hazard ratio, Acute kidney injury, Interleukin, Pathogenesis and modulation of inflammation Infection and autoimmunity [N4i 1], Acute Kidney Injury, Middle Aged, medicine.disease, Interleukin-10, Interleukin 10, Infectious Diseases, Immunology, biology.protein, Female, business, medicine.drug |
| الوصف: | Item does not contain fulltext OBJECTIVES: The underlying mechanism for amphotericin B-induced acute kidney injury (AKI) remains poorly understood and may be immunologically mediated. We assessed whether the development of nephrotoxicity is linked to a distinct cytokine profile in patients receiving amphotericin B deoxycholate (AmBD). PATIENTS AND METHODS: In 58 patients who received AmBD, circulating serum interleukin (IL)-6, IL-8 and IL-10 were measured at baseline, week 1 and week 2 of antifungal treatment and correlated to the development of renal impairment. The Cox proportional hazards model approach was adopted for analysis. RESULTS: The P value was 0.026 for the overall effect of IL-6 on time to development of AKI. An increasing or non-receding IL-6 trend by week 1 of AmBD treatment (followed by a decreasing or non-receding IL-6 trend from week 1 to week 2) correlated with an increased likelihood of nephrotoxicity [hazard ratio (HR) 6.93, P value 0.005 and HR 3.46, P value 0.035, respectively]. Similarly, persistently increasing IL-8 levels were linked to a 3.84-fold increased likelihood of AKI. CONCLUSIONS: In patients receiving AmBD, persistence of an elevated pro-inflammatory cytokine milieu is associated with a predisposition to drug-related kidney injury. |
| تدمد: | 1460-2091 0305-7453 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b7c72d69e14090e4ce850ffffb4959eTest https://pure.eur.nl/en/publications/47067dc5-a9a8-4570-9472-858f906326c1Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....0b7c72d69e14090e4ce850ffffb4959e |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14602091 03057453 |
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