Multi-parametric magnetic resonance imaging assessment of whole tumour heterogeneity for chemoradiotherapy response prediction in rectal cancer
| العنوان: | Multi-parametric magnetic resonance imaging assessment of whole tumour heterogeneity for chemoradiotherapy response prediction in rectal cancer |
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| المؤلفون: | Minh Xuan Truong, Michael Barton, Joo-Shik Shin, Gary P Liney, Petra L. Graham, Robba Rai, Trang Pham, Christopher Henderson, Karen Wong, Malcolm Hudson, Nira Borok, Mark T Lee |
| المصدر: | Physics and Imaging in Radiation Oncology, Vol 18, Iss, Pp 26-33 (2021) Physics and Imaging in Radiation Oncology |
| بيانات النشر: | Elsevier BV, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | medicine.medical_specialty, Tumour heterogeneity, Colorectal cancer, R895-920, 030218 nuclear medicine & medical imaging, Medical physics. Medical radiology. Nuclear medicine, 03 medical and health sciences, 0302 clinical medicine, Rectal Adenocarcinoma, Medicine, Effective diffusion coefficient, Radiology, Nuclear Medicine and imaging, Original Research Article, cardiovascular diseases, RC254-282, Radiation, medicine.diagnostic_test, business.industry, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Magnetic resonance imaging, medicine.disease, Clinical trial, 030220 oncology & carcinogenesis, Radiology, business, Chemoradiotherapy, Diffusion MRI |
| الوصف: | Highlights • Diffusion weighted imaging of heterogeneity can aid selection for ‘watch-and-wait’. • Apparent diffusion coefficient 75th and 90th quantiles were predictive of response. • Dynamic contrast enhanced imaging did not add value in response prediction. • Functional mapping of tumour heterogeneity may be used for targeting. Background and purpose Prediction of chemoradiotherapy response (CRT) in locally advanced rectal cancer would enable stratification of management. The purpose was to prospectively evaluate multi-parametric magnetic resonance imaging (MRI) assessment of tumour heterogeneity combining diffusion weighted imaging (DWI) and dynamic contrast enhanced (DCE) MRI for the prediction of CRT response in locally advanced rectal cancer. Materials and methods Patients with Stage II or III rectal adenocarcinoma undergoing neoadjuvant CRT and surgery underwent MRI (DWI and DCE) before, during (week 3), and after CRT (1 week before surgery). Patients with histopathology tumour regression grade (TRG) 0–1 were classified as responders, and TRG 2–3 were classified as non-responders. A whole tumour voxel-wise technique was used to produce apparent diffusion coefficient (ADC) and Ktrans (Tofts model) histograms derived from DWI and DCE-MRI, respectively. Logistic regression was used to predict response status for ADC and Ktrans quantiles. Results Thirty-three patients were included in this analysis; 16 responders, and 17 non-responders. On heterogeneity analysis, odds of being a responder were significantly higher after CRT (before surgery) for higher ADC 75th (p = 0.049) and ADC 90th (p = 0.034) percentile values. The Ktrans quantiles were lower in non-responders than responders before and during CRT, and higher after CRT although no significant association with response status was observed (p ≥ 0.10). Conclusions DWI-MRI after CRT (before surgery) incorporating a histogram analysis of whole tumour heterogeneity was predictive of CRT response in patients with locally advanced rectal cancer. DCE-MRI did not add value in response prediction. Clinical trial registration Australian New Zealand Clinical Trials Registry (ANZCTR) number ACTRN12616001690448. |
| تدمد: | 2405-6316 1261-6001 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b751588ec583855a67b0dd236f21048Test https://doi.org/10.1016/j.phro.2021.03.003Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....0b751588ec583855a67b0dd236f21048 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 24056316 12616001 |
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