Airway Surface Liquid pH Regulation in Airway Epithelium Current Understandings and Gaps in Knowledge
| العنوان: | Airway Surface Liquid pH Regulation in Airway Epithelium Current Understandings and Gaps in Knowledge |
|---|---|
| المؤلفون: | Aurélie Edwards, Gabrielle Planelles, Miroslaw Zajac, Elise Dreano, Isabelle Sermet-Gaudelus |
| المصدر: | International Journal of Molecular Sciences, Vol 22, Iss 3384, p 3384 (2021) International Journal of Molecular Sciences |
| بيانات النشر: | MDPI AG, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Cystic Fibrosis, ATPase, Cystic Fibrosis Transmembrane Conductance Regulator, Review, Antiporters, Epithelium, lcsh:Chemistry, chemistry.chemical_compound, Mice, Chloride-Bicarbonate Antiporters, CFTR, lcsh:QH301-705.5, Spectroscopy, Carbonic Anhydrases, biology, pH, General Medicine, respiratory system, Hydrogen-Ion Concentration, Computer Science Applications, Trachea, Sulfate Transporters, Paracellular transport, Rabbits, Sodium, Bicarbonate, chemistry.chemical_element, Respiratory Mucosa, Catalysis, lung, Inorganic Chemistry, Carbonic anhydrase, TheoryofComputation_ANALYSISOFALGORITHMSANDPROBLEMCOMPLEXITY, otorhinolaryngologic diseases, SLC26A4, Animals, Humans, Secretion, Physical and Theoretical Chemistry, Molecular Biology, Organic Chemistry, Epithelial Cells, Pendrin, ATP12A, Bicarbonates, HEK293 Cells, chemistry, lcsh:Biology (General), lcsh:QD1-999, biology.protein, Biophysics, Respiratory epithelium |
| الوصف: | Knowledge on the mechanisms of acid and base secretion in airways has progressed recently. The aim of this review is to summarize the known mechanisms of airway surface liquid (ASL) pH regulation and their implication in lung diseases. Normal ASL is slightly acidic relative to the interstitium, and defects in ASL pH regulation are associated with various respiratory diseases, such as cystic fibrosis. Basolateral bicarbonate (HCO3−) entry occurs via the electrogenic, coupled transport of sodium (Na+) and HCO3−, and, together with carbonic anhydrase enzymatic activity, provides HCO3− for apical secretion. The latter mainly involves CFTR, the apical chloride/bicarbonate exchanger pendrin and paracellular transport. Proton (H+) secretion into ASL is crucial to maintain its relative acidity compared to the blood. This is enabled by H+ apical secretion, mainly involving H+/K+ ATPase and vacuolar H+-ATPase that carry H+ against the electrochemical potential gradient. Paracellular HCO3− transport, the direction of which depends on the ASL pH value, acts as an ASL protective buffering mechanism. How the transepithelial transport of H+ and HCO3− is coordinated to tightly regulate ASL pH remains poorly understood, and should be the focus of new studies. |
| اللغة: | English |
| تدمد: | 1661-6596 1422-0067 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b1ef0400d166e5c9fdfa66acaa5ab2aTest https://www.mdpi.com/1422-0067/22/7/3384Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....0b1ef0400d166e5c9fdfa66acaa5ab2a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16616596 14220067 |
|---|