Effects of ezetimibe/simvastatin 10/10 mg versus Rosuvastatin 10 mg on carotid atherosclerotic plaque inflammation
| العنوان: | Effects of ezetimibe/simvastatin 10/10 mg versus Rosuvastatin 10 mg on carotid atherosclerotic plaque inflammation |
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| المؤلفون: | Cheol Whan Lee, Changhwan Sung, Dae Hyuk Moon, Eon Woo Shin, Hyunji Kim, Minyoung Oh, Do Hoon Kim |
| المصدر: | BMC Cardiovascular Disorders, Vol 19, Iss 1, Pp 1-7 (2019) BMC Cardiovascular Disorders |
| بيانات النشر: | BMC, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Carotid Artery Diseases, Male, medicine.medical_specialty, Acute coronary syndrome, Positron emission tomography, lcsh:Diseases of the circulatory (Cardiovascular) system, Time Factors, Statin, Seoul, medicine.drug_class, Anti-Inflammatory Agents, Urology, Ezetimibe, Simvastatin Drug Combination, 030204 cardiovascular system & hematology, 03 medical and health sciences, 0302 clinical medicine, Ezetimibe, Fluorodeoxyglucose F18, Predictive Value of Tests, Positron Emission Tomography Computed Tomography, medicine.artery, medicine, Humans, Rosuvastatin, 030212 general & internal medicine, Rosuvastatin Calcium, Aged, Angiology, Inflammation, Aorta, business.industry, Plaque inflammation, nutritional and metabolic diseases, Middle Aged, medicine.disease, Plaque, Atherosclerotic, Treatment Outcome, Simvastatin, lcsh:RC666-701, Female, Ezetimibe/simvastatin, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Radiopharmaceuticals, Cardiology and Cardiovascular Medicine, business, Research Article, medicine.drug |
| الوصف: | Background Using 18F-fluorodeoxyglucose (18FDG) positron emission tomography-computed tomography (PET/CT) imaging, we examined the effects of ezetimibe/simvastatin 10/10 mg versus rosuvastatin 10 mg on carotid atherosclerotic plaque inflammation. Whether the combination therapy of ezetimibe with low-dose statin is as effective as potent statin monotherapy in attenuating carotid atherosclerotic plaque inflammation remains unclear. Methods In this 2-by-2 factorial trial, 50 patients with 18FDG uptake (target-to-background ratio [TBR] ≥1.6) in the carotid artery and acute coronary syndrome were randomized to receive either simvastatin/ezetimibe 10/10 mg or rosuvastatin 10 mg. 18FDG PET/CT examinations were performed at baseline and at 6 months. The percent change in the TBR of the index vessel at the most diseased segment (MDS) was the primary endpoint. Results Baseline characteristics of the two groups were largely similar. At 6-month follow-up, the MDS TBR of the index vessel and aorta significantly decreased in ezetimibe/simvastatin group and tended to decrease in rosuvastatin group. However, the percent change in the MDS TBR of the index vessel was similar between the 2 groups (− 10.22 ± 17.49% vs. -5.84 ± 15.78%, respectively, p = 0.357), as was the percent change in the whole vessel TBR of the index vessel. Likewise, the changes in the MDS TBR or whole vessel TBR of the aorta were similar in both groups. Total cholesterol and low-density lipoprotein cholesterol levels improved to a similar degree in both groups. Conclusion Treatment with ezetimibe/simvastatin versus rosuvastatin resulted in a similar improvement of carotid atherosclerotic plaque inflammation, suggesting their equivalent anti-inflammatory effects. Trial registration The trial is registered at ClinicalTrials.gov: NCT02378064, 3-4-2015. /IRB No. 2015–0194. |
| اللغة: | English |
| تدمد: | 1471-2261 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b126ccdf09fad5406fba10e949db788Test http://link.springer.com/article/10.1186/s12872-019-1184-2Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....0b126ccdf09fad5406fba10e949db788 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14712261 |
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