Thrombogenic Factors and Recurrent Coronary Events
| العنوان: | Thrombogenic Factors and Recurrent Coronary Events |
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| المؤلفون: | Luc F. Miller Watelet, Robert E. Goldstein, Edgar Lichstein, Monty M. Bodenheimer, Ronald J. Krone, Henry Greenberg, Harvey J. Weiss, Arthur J. Moss, Frank I. Marcus, Lucy Van Voorhees, Rohit Arora, Victor J. Marder, John A. Gillespie, Robert B. Case, Charles E. Sparks, Chang-seng Liang, Edward M. Dwyer, Mary W. Brown, Wojciech Zareba, David Oakes, Judith S. Hochman, William C. Little |
| المصدر: | Circulation. 99:2517-2522 |
| بيانات النشر: | Ovid Technologies (Wolters Kluwer Health), 1999. |
| سنة النشر: | 1999 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Apolipoprotein B, Myocardial Infarction, Factor VIIa, Fibrin Fibrinogen Degradation Products, chemistry.chemical_compound, Von Willebrand factor, Recurrence, Risk Factors, Physiology (medical), Internal medicine, Plasminogen Activator Inhibitor 1, von Willebrand Factor, medicine, Humans, Insulin, Prospective Studies, Myocardial infarction, Aged, Hemostasis, biology, Factor VII, business.industry, Cholesterol, Fibrinogen, Thrombosis, Middle Aged, medicine.disease, Lipids, Endocrinology, chemistry, biology.protein, Cardiology, Female, lipids (amino acids, peptides, and proteins), Cardiology and Cardiovascular Medicine, business, Lipoprotein |
| الوصف: | Background —Thrombosis is a pivotal event in the pathogenesis of coronary disease. We hypothesized that the presence of blood factors that reflect enhanced thrombogenic activity would be associated with an increased risk of recurrent coronary events during long-term follow-up of patients who have recovered from myocardial infarction. Methods and Results —We prospectively enrolled 1045 patients 2 months after an index myocardial infarction. Baseline thrombogenic blood tests included 6 hemostatic variables ( d -dimer, fibrinogen, factor VII, factor VIIa, von Willebrand factor, and plasminogen activator inhibitor-1), 7 lipid factors [cholesterol, triglycerides, HDL cholesterol, LDL cholesterol, lipoprotein(a), apolipoprotein (apo)A-I, and apoB], and insulin. Patients were followed up for an average of 26 months, with the primary end point being coronary death or nonfatal myocardial infarction, whichever occurred first. The hemostatic, lipid, and insulin parameters were dichotomized into their top and the lower 3 risk quartiles and evaluated for entry into a Cox survivorship model. High levels of d -dimer (hazard ratio, 2.43; 95% CI, 1.49, 3.97) and apoB (hazard ratio, 1.82; 95% CI, 1.10, 3.00) and low levels of apoA-I (hazard ratio, 1.84; 95% CI, 1.10, 3.08) were independently associated with recurrent coronary events in the Cox model after adjustment for 6 relevant clinical covariates. Conclusions —Our findings indicate that a procoagulant state, as reflected in elevated levels of d -dimer, and disordered lipid transport, as indicated by low apoA-1 and high apoB levels, contribute independently to recurrent coronary events in postinfarction patients. |
| تدمد: | 1524-4539 0009-7322 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0aa2691c8260a4dcf98e03f01cfdfc5fTest https://doi.org/10.1161/01.cir.99.19.2517Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....0aa2691c8260a4dcf98e03f01cfdfc5f |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15244539 00097322 |
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