Autophagy manipulation as a strategy for efficient anticancer therapies: possible consequences
| العنوان: | Autophagy manipulation as a strategy for efficient anticancer therapies: possible consequences |
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| المؤلفون: | Maria Saveria Gilardini Montani, Alessia Garufi, Marisa Granato, Gabriella D'Orazi, Alberto Faggioni, Mara Cirone |
| المصدر: | Journal of Experimental & Clinical Cancer Research : CR Journal of Experimental & Clinical Cancer Research, Vol 38, Iss 1, Pp 1-7 (2019) |
| بيانات النشر: | BioMed Central, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | 0301 basic medicine, p53, Cancer Research, Programmed cell death, Unfolded protein response (UPR), Antineoplastic Agents, Apoptosis, Review, autophagy, cancer, chloroquine (CQ), endoplasmic reticulum (ER stress), HSF1, hydroxichloroquine (HCQ), immunogenic cell death (ICD), NRF2, unfolded protein response (UPR), animals, antineoplastic agents, apoptosis, endoplasmic reticulum stress, gene zxpression regulation, neoplastic, humans, molecular targeted therapy, neoplasms, oncogenes, signal transduction, unfolded protein response, lcsh:RC254-282, 03 medical and health sciences, 0302 clinical medicine, Immune system, Hydroxichloroquine (HCQ), Endoplasmic reticulum (ER stress), Neoplasms, Autophagy, Medicine, Animals, Humans, Molecular Targeted Therapy, Cancer, gene zxpression regulation, business.industry, Oncogenes, Catabolic Process, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, medicine.disease, Endoplasmic Reticulum Stress, neoplastic, Gene Expression Regulation, Neoplastic, 030104 developmental biology, Oncology, Chloroquine (CQ), 030220 oncology & carcinogenesis, Cancer cell, Cancer research, Unfolded Protein Response, business, Immunogenic cell death (ICD), Signal Transduction |
| الوصف: | Autophagy is a catabolic process whose activation may help cancer cells to adapt to cellular stress although, in some instances, it can induce cell death. Autophagy stimulation or inhibition has been considered an opportunity to treat cancer, especially in combination with anticancer therapies, although autophagy manipulation may be viewed as controversial. Thus, whether to induce or to inhibit autophagy may be the best option in the different cancer patients is still matter of debate. Her we will recapitulate the possible advantages or disadvantages of manipulating autophagy in cancer, not only with the aim to obtain cancer cell death and disable oncogenes, but also to evaluate its interplay with the immune response which is fundamental for the success of anticancer therapies. |
| اللغة: | English |
| تدمد: | 1756-9966 0392-9078 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a1eb9a2235fdcf2b3d6237b566d18bbTest http://europepmc.org/articles/PMC6570888Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....0a1eb9a2235fdcf2b3d6237b566d18bb |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17569966 03929078 |
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