Immune recovery in acute and chronic HIV infection and the impact of thymic stromal lymphopoietin
| العنوان: | Immune recovery in acute and chronic HIV infection and the impact of thymic stromal lymphopoietin |
|---|---|
| المؤلفون: | Marco Gelpi, Henrik Ullum, Hans J. Hartling, Susanne Dam Nielsen, Kristina Thorsteinsson, Jan Gerstoft |
| المصدر: | BMC Infectious Diseases, Vol 16, Iss 1, Pp 1-9 (2016) BMC Infectious Diseases |
| بيانات النشر: | BMC, 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | 0301 basic medicine, Cart, Adult, CD4-Positive T-Lymphocytes, Male, medicine.medical_specialty, Thymic stromal lymphopoietin, Anti-HIV Agents, medicine.medical_treatment, T cell, Recent Thymic Emigrant, HIV Infections, Biology, Flow cytometry, lcsh:Infectious and parasitic diseases, 03 medical and health sciences, 0302 clinical medicine, Medical microbiology, Thymic Stromal Lymphopoietin, medicine, Humans, Primary HIV infection, lcsh:RC109-216, 030212 general & internal medicine, Prospective Studies, Chronic HIV infection, medicine.diagnostic_test, Interleukin-7, virus diseases, HIV, Middle Aged, CD4 Lymphocyte Count, 030104 developmental biology, Cytokine, medicine.anatomical_structure, Infectious Diseases, Case-Control Studies, TSLP, Immunology, Chronic Disease, Cytokines, Female, Homeostasis, Biomarkers, Research Article |
| الوصف: | Background Symptomatic primary HIV infection is associated with an adverse prognosis, and immediate initiation of combination antiretroviral therapy (cART) is recommended. However, little is known about immunological predictors of immune recovery. Thymic Stromal Lymphopoietin (TSLP) is a cytokine that promotes CD4+ T cells homeostatic polyclonal proliferation and regulates Th17/regulatory T-cell balance, immunological functions known to be affected during primary HIV infection. The aim of this study was to describe immune recovery in primary and chronic HIV infection and possible impact of TSLP. Methods Prospective study including 100 HIV-infected individuals (primary HIV infection (N = 14), early presenters (>350 CD4+ T cells/μL, N = 42), late presenters without advanced disease (200–350 CD4+ T cells/μL, N = 24) and with advanced disease ( |
| اللغة: | English |
| تدمد: | 1471-2334 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09c812c082480615e4d54bec56c74c9eTest http://link.springer.com/article/10.1186/s12879-016-1930-3Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....09c812c082480615e4d54bec56c74c9e |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14712334 |
|---|