Extracellular vesicles in coronary artery disease
| العنوان: | Extracellular vesicles in coronary artery disease |
|---|---|
| المؤلفون: | Xavier Loyer, Nicolas Amabile, Chantal M. Boulanger, Pierre-Emmanuel Rautou |
| المساهمون: | Paris-Centre de Recherche Cardiovasculaire (PARCC (UMR_S 970/ U970)), Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), Hôpital Beaujon [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Université Paris Diderot, Sorbonne Paris Cité, Paris, France, Université Paris Diderot - Paris 7 (UPD7), DHU addressing Unmet Needs through Innovation in hepaTology and gastroenterologY [Paris] (DHU UNITY [APHP]), Institut mutualiste Monsouris (IMM), Boulanger, Chantal |
| المصدر: | Nature Reviews Cardiology Nature Reviews Cardiology, Nature Publishing Group, 2017, 14 (5), pp.259-272. ⟨10.1038/nrcardio.2017.7⟩ |
| بيانات النشر: | Springer Science and Business Media LLC, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | 0301 basic medicine, plaque rupture, Pathology, medicine.medical_specialty, Inflammation, Cell Communication, Coronary Artery Disease, exosomes, 030204 cardiovascular system & hematology, Second Messenger Systems, calcification, Cell therapy, Extracellular Vesicles, 03 medical and health sciences, 0302 clinical medicine, [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, Drug Discovery, medicine, Extracellular, Humans, Lipid bilayer, business.industry, Vesicle, Microvesicles, [SDV.MHEP.CSC] Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, Cell biology, Cytosol, 030104 developmental biology, biomarker, atherosclerosis, Stem cell, medicine.symptom, Cardiology and Cardiovascular Medicine, business, microvesicles, Biomarkers |
| الوصف: | International audience; Membrane vesicles released in the extracellular space are composed of a lipid bilayer enclosing soluble cytosolic material and nuclear components. Extracellular vesicles include apoptotic bodies, exosomes, and microvesicles (also known previously as microparticles). Originating from different subcellular compartments, the role of extracellular vesicles as regulators of transfer of biological information, acting locally and remotely, is now acknowledged. Circulating vesicles released from platelets, erythrocytes, leukocytes, and endothelial cells contain potential valuable biological information for biomarker discovery in primary and secondary prevention of coronary artery disease. Extracellular vesicles also accumulate in human atherosclerotic plaques, where they affect major biological pathways, including inflammation, proliferation, thrombosis, calcification, and vasoactive responses. Extracellular vesicles also recapitulate the beneficial effect of stem cells to treat cardiac consequences of acute myocardial infarction, and now emerge as an attractive alternative to cell therapy, opening new avenues to vectorize biological information to target tissues. Although interest in microvesicles in the cardiovascular field emerged about 2 decades ago, that for extracellular vesicles, in particular exosomes, started to unfold a decade ago, opening new research and therapeutic avenues. This Review summarizes current knowledge on the role of extracellular vesicles in coronary artery disease, and their emerging potential as biomarkers and therapeutic agents. |
| وصف الملف: | application/pdf |
| تدمد: | 1759-5010 1759-5002 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0993d3a85c8ef6e8fd5dd071b6e8f896Test https://doi.org/10.1038/nrcardio.2017.7Test |
| حقوق: | EMBARGO |
| رقم الانضمام: | edsair.doi.dedup.....0993d3a85c8ef6e8fd5dd071b6e8f896 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17595010 17595002 |
|---|