Protective effect of extract of the Camellia japonica L. on cerebral ischemia-reperfusion injury in rats
| العنوان: | Protective effect of extract of the Camellia japonica L. on cerebral ischemia-reperfusion injury in rats |
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| المؤلفون: | Ling Xv, Jiyue Wen, Weizhuo Lu |
| المصدر: | Arquivos de Neuro-Psiquiatria, Vol 77, Iss 1, Pp 39-46 Arquivos de Neuro-Psiquiatria v.77 n.1 2019 Arquivos de neuro-psiquiatria Academia Brasileira de Neurologia instacron:ABNEURO Arquivos de Neuro-Psiquiatria, Volume: 77, Issue: 1, Pages: 39-46, Published: JAN 2019 |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Male, Time Factors, Pharmacology, Japonica, Brain Ischemia, Brain ischemia, Rats, Sprague-Dawley, chemistry.chemical_compound, Random Allocation, 0302 clinical medicine, Malondialdehyde, Medicine, 030212 general & internal medicine, biology, food and beverages, Camellia, Extravasation, Neuroprotective Agents, Treatment Outcome, Neurology, Reperfusion Injury, Female, barreira hematoencefálica, Ischemia, lcsh:RC321-571, 03 medical and health sciences, Lactate dehydrogenase, Animals, lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry, Swimming, Isquemia encefálica, L-Lactate Dehydrogenase, business.industry, Plant Extracts, Reproducibility of Results, blood-brain barrier, medicine.disease, biology.organism_classification, Disease Models, Animal, Camellia japonica, chemistry, Immunoglobulin G, Nimodipine, Neurology (clinical), business, Reperfusion injury, 030217 neurology & neurosurgery |
| الوصف: | Objective: We investigated the protective effect of the extract of the Camellia japonica L. flower on cerebral ischemia-reperfusion injury in rats. Methods: The rat ischemia-reperfusion injury was induced by middle cerebral artery occlusion for 90 minutes and reperfusion for 48 hours. The animals received an intravenous injection once a day of 20, 40, 80 mg/kg extract of C. japonica for three consecutive days before the ischemia reperfusion. The learning and memory function, the infarct volume, serum malondialdehyde (MDA) level and lactate dehydrogenase activity, and extravasation of immunoglobulin G (IgG) into cerebral parenchyma were assessed as the cell damage index. Results: Pretreatment with extract of C. japonica markedly reduced the infarct volume, serum malondialdehyde level and lactate dehydrogenase activity, and markedly inhibited the extravasation of IgG. Moreover, pretreatment with extract of C. japonica may also inhibit the learning and memory deficits induced by an ischemia-reperfusion injury. Conclusion: It was concluded that pretreatment with extract of C. japonica has a protective effect on cerebral ischemia-reperfusion injury in rats. RESUMO Objetivo: Investigamos o efeito protetor do extrato da flor de Camellia japonica L. (ECJ) na lesão de reperfusão isquêmica cerebral (I/R) em ratos. Métodos: A lesão de I/R de rato foi induzida por uma oclusão da artéria cerebral média por 90 minutos e reperfusão por 48 horas. Os animais receberam uma injeção intravenosa uma vez ao dia de 20, 40, 80 mg/kg de ECJ por três dias consecutivos antes da I/R. A função de aprendizagem e memória, o volume do infarto, o nível sérico de malondialdeído (MDA), a atividade da desidrogenase láctica e o extravasamento de imunoglobulina (IgG) no parênquima cerebral foram avaliados como índices de dano celular. Resultados: O pré-tratamento com ECJ reduziu acentuadamente o volume do infarto, o nível sérico de MDA e a atividade da desidrogenase láctica, e inibiu marcadamente o extravasamento de IgG. Além disso, o pré-tratamento com ECJ também poderia inibir os déficits de aprendizado e memória induzidos pela lesão de I/R. Conclusão: O pré-tratamento com ECJ tem um efeito protetor contra lesão cerebral de I/R em ratos. |
| وصف الملف: | text/html |
| تدمد: | 1678-4227 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0979c0c2a138acd494636ea983c618e0Test https://pubmed.ncbi.nlm.nih.gov/30758441Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....0979c0c2a138acd494636ea983c618e0 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16784227 |
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