Salivary cytokine profile in patients with ischemic stroke
| العنوان: | Salivary cytokine profile in patients with ischemic stroke |
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| المؤلفون: | Mateusz Maciejczyk, Piotr Gerreth, Kacper Maksymilian Mil, Karolina Gerreth, Katarzyna Hojan, Anna Zalewska |
| المصدر: | Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021) Scientific Reports |
| بيانات النشر: | Nature Portfolio, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, Chemokine, Saliva, Science, Inflammation, Predictive markers, Gastroenterology, Article, Pathogenesis, Prognostic markers, Internal medicine, medicine, Humans, Cognitive decline, Interleukin 6, Stroke, Aged, Ischemic Stroke, Multidisciplinary, biology, Interleukin-6, Tumor Necrosis Factor-alpha, business.industry, Diagnostic markers, Middle Aged, medicine.disease, Interleukin-10, Interleukin 10, biology.protein, Medicine, Female, medicine.symptom, business, Biomarkers |
| الوصف: | Inflammation plays a crucial role in stroke pathogenesis. Thus, it is not surprising that cytokines, chemokines, and growth factors have been advocated in stroke diagnostics. Our study is the first to evaluate the salivary cytokine profile in patients with ischemic stroke. Twenty-five patients with subacute ischemic stroke and an age-, sex-, and oral hygiene status-matched control group were enrolled in the study. The number of patients was set a priori based on our previous experiment (α = 0.05, test power = 0.9). Salivary concentrations of tumor necrosis factor α (TNF-α), interleukin 6 (IL-6), and interleukin 10 (IL-10) were assessed using an ELISA method. We showed that salivary TNF-α and IL-6 were significantly higher, whereas IL-10 content was statistically lower in both non-stimulated (NWS) and stimulated (SWS) whole saliva of ischemic stroke patients. However, evaluation of cytokines in NWS rather than in SWS may be of greater diagnostic value. Of particular note is salivary TNF-α, which may indicate cognitive/physical impairment in post-stroke individuals. This parameter distinguishes stroke patients from healthy controls and correlates with cognitive decline and severity of functional impairment. It also differentiates (with high sensitivity and specificity) stroke patients with normal cognition from mild to moderate cognitive impairment. Saliva may be an alternative to blood for assessing cytokines in stroke patients, although further studies on a larger patient population are needed. |
| اللغة: | English |
| تدمد: | 2045-2322 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::096b04ac1ae95774f4e142af659f88c0Test https://doaj.org/article/5016893d3611498a92c46cc4fd418b14Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....096b04ac1ae95774f4e142af659f88c0 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20452322 |
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