International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G Protein–Coupled Receptors
| العنوان: | International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G Protein–Coupled Receptors |
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| المؤلفون: | Thue W. Schwartz, Uwe Wolfrum, Xianhua Piao, Robert Fredriksson, Yuri A. Ushkaryov, Jörg Hamann, Simone Prömel, Hsi-Hsien Lin, Torsten Schöneberg, Helgi B. Schiöth, Ines Liebscher, Felix B. Engel, Gabriela Aust, Kathleen Singer, Tobias Langenhan, Miriam C. Peeters, Barbara Knapp, Arunkumar Krishnan, Martin Stacey, Caroline J. Formstone, David C. Martinelli, Mario Vallon, Breanne L. Harty, Kelly Monk, Randy A. Hall, Demet Araç, Mathew W. Wright, Christiane Kirchhoff, Lei Xu |
| المصدر: | Pharmacological Reviews. 67:338-367 |
| بيانات النشر: | American Society for Pharmacology & Experimental Therapeutics (ASPET), 2015. |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | Models, Molecular, Societies, Scientific, Subfamily, Computational biology, Biology, GPR110, Pharmacology, Ligands, GPR113, Second Messenger Systems, Receptors, G-Protein-Coupled, Cell Movement, Terminology as Topic, Cell Adhesion, Cyclic AMP, Animals, Humans, Protein Isoforms, Receptor, Nomenclature, G protein-coupled receptor, Cell Membrane, International Agencies, Adhesion, QP, GPR56, Pharmacology, Clinical, IUPHAR Nomenclature Reports, Molecular Medicine, QP517, Cell Adhesion Molecules, Signal Transduction |
| الوصف: | The Adhesion family forms a large branch of the pharmacologically important superfamily of G protein-coupled receptors (GPCRs). As Adhesion GPCRs increasingly receive attention from a wide spectrum of biomedical fields, the Adhesion GPCR Consortium, together with the International Union of Basic and Clinical Pharmacology Committee on Receptor Nomenclature and Drug Classification, proposes a unified nomenclature for Adhesion GPCRs. The new names have ADGR as common dominator followed by a letter and a number to denote each subfamily and subtype, respectively. The new names, with old and alternative names within parentheses, are: ADGRA1 (GPR123), ADGRA2 (GPR124), ADGRA3 (GPR125), ADGRB1 (BAI1), ADGRB2 (BAI2), ADGRB3 (BAI3), ADGRC1 (CELSR1), ADGRC2 (CELSR2), ADGRC3 (CELSR3), ADGRD1 (GPR133), ADGRD2 (GPR144), ADGRE1 (EMR1, F4/80), ADGRE2 (EMR2), ADGRE3 (EMR3), ADGRE4 (EMR4), ADGRE5 (CD97), ADGRF1 (GPR110), ADGRF2 (GPR111), ADGRF3 (GPR113), ADGRF4 (GPR115), ADGRF5 (GPR116, Ig-Hepta), ADGRG1 (GPR56), ADGRG2 (GPR64, HE6), ADGRG3 (GPR97), ADGRG4 (GPR112), ADGRG5 (GPR114), ADGRG6 (GPR126), ADGRG7 (GPR128), ADGRL1 (latrophilin-1, CIRL-1, CL1), ADGRL2 (latrophilin-2, CIRL-2, CL2), ADGRL3 (latrophilin-3, CIRL-3, CL3), ADGRL4 (ELTD1, ETL), and ADGRV1 (VLGR1, GPR98). This review covers all major biologic aspects of Adhesion GPCRs, including evolutionary origins, interaction partners, signaling, expression, physiologic functions, and therapeutic potential. |
| وصف الملف: | application/pdf |
| تدمد: | 1521-0081 0031-6997 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08eff832d0f2ad2e843d6eef21176285Test https://doi.org/10.1124/pr.114.009647Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....08eff832d0f2ad2e843d6eef21176285 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15210081 00316997 |
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