Remote ischemic conditioning with exercise (RICE) promotes functional rehabilitation following ischemic stroke
| العنوان: | Remote ischemic conditioning with exercise (RICE) promotes functional rehabilitation following ischemic stroke |
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| المؤلفون: | Xiaokun Geng, Melissa Wills, Fengwu Li, Qingzhu Wang, Yuchuan Ding |
| المصدر: | Neurological Research. 43:874-883 |
| بيانات النشر: | Informa UK Limited, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Male, 0301 basic medicine, Angiogenesis, medicine.medical_treatment, Morris water navigation task, Rats, Sprague-Dawley, 03 medical and health sciences, 0302 clinical medicine, Physical Conditioning, Animal, Ischemic conditioning, Neuroplasticity, medicine, Animals, Ischemic Postconditioning, Stroke, Ischemic Stroke, Functional rehabilitation, Rehabilitation, business.industry, Stroke Rehabilitation, General Medicine, medicine.disease, Rats, 030104 developmental biology, Neurology, Anesthesia, Ischemic stroke, Neurology (clinical), business, 030217 neurology & neurosurgery |
| الوصف: | Objective: Exercise is an essential rehabilitative strategy after stroke butits implementation is limited as its very early use can exacerbate damage and is restricted by patient disability. Remote Ischemic Conditioning (RIC) is a safe alternative for post-stroke neuroprotetion. The present study investigated the neurorehabilitative benefits of early RIC followed by exercise (RICE) therapy.Methods: 48 adult male Sprague-Dawley rats were divided into groups: 1) sham, 2) stroke, 3) stroke with RICE at day 3 (RIC 6 hours after reperfusion followed by exercise days 3 to 28), 4) stroke with exercise at day 3 (exercise days 3 to 28), and 5) stroke with RICE at day 1 (RIC 6 hours after reperfusion followed by exercise days 1 to 28), 6) stroke with exercise at day 1 (exercise days 1 to 28 after reperfusion). Long-term functional outcomes were determined by grid walk, rota-rod, adhesive tape touch, and Morris water maze. Levels of mRNA and proteins of neuroplasticity, synaptogenesis, and angiogenesis, were determined.Results: As compared to exercise only, animals that underwent RICE had significant improvements in functional outcomes after stroke. These improvements were most significant in groups that had the later initiation of exercise. In addition, all treatment groups showed significant increases in mRNA and protein expression of the target molecules for neuroplasticity, synaptogenesis, and angiogenesis, while further significant increases were observed after RICE following ischemic stroke.Conclusions: RICE, a novel therapy that supplements RIC prior to exercise, is superiorly effective in inducing rehabilitation after stroke as compared to the traditional exercise monotherapy rehabilitation in rats with ischemic brain injury. |
| تدمد: | 1743-1328 0161-6412 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0877542e641b8df1af999bcf0434fc95Test https://doi.org/10.1080/01616412.2021.1939489Test |
| رقم الانضمام: | edsair.doi.dedup.....0877542e641b8df1af999bcf0434fc95 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17431328 01616412 |
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