Biogenic selenium and its hepatoprotective activity
| العنوان: | Biogenic selenium and its hepatoprotective activity |
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| المؤلفون: | Dan Li, Shao-chin Lee, Lan Wang, Baozhen Li, Hans-Uwe Dahms, Jinhua Fan, Weixin Jing |
| المصدر: | Scientific Reports Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017) |
| بيانات النشر: | Nature Publishing Group UK, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | 0301 basic medicine, Antioxidant, Thioredoxin-Disulfide Reductase, medicine.medical_treatment, lcsh:Medicine, chemistry.chemical_element, Metal Nanoparticles, 02 engineering and technology, Pharmacology, Article, Antioxidants, Cell Line, Superoxide dismutase, 03 medical and health sciences, chemistry.chemical_compound, Mice, Selenium, Sodium Selenite, Lactate dehydrogenase, medicine, Animals, Humans, lcsh:Science, Carbon Tetrachloride, chemistry.chemical_classification, Glutathione Peroxidase, Multidisciplinary, biology, Chemistry, Carbon Tetrachloride Poisoning, Glutathione peroxidase, Liver cell, lcsh:R, 021001 nanoscience & nanotechnology, 030104 developmental biology, Catalase, biology.protein, Alkaline phosphatase, lcsh:Q, Chemical and Drug Induced Liver Injury, 0210 nano-technology |
| الوصف: | Elemental selenium nanoparticles (SeNPs) have multiple biological activities. In this study, we investigated the protective effects of biogenic SeNPs (BioSeNPs) on CCl4-induced liver damage in mice. The results showed that: (i) when compared to sodium selenite (SS), BioSeNPs has a similar tissue distribution after intragastrical administration to mice; (ii) BioSeNPs and SS showed comparable efficacy in increasing the activities of glutathione peroxidase and thioredoxin reductase in liver cell lines, mice blood and liver; (iii) pretreatment with BioSeNPs inhibiting the elevation of activities of various enzymes significantly which included aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, lactate dehydrogenase and liver lipid peroxide (p 4-treated mice; (iv) activities of antioxidant enzymes (superoxide dismutase, catalase, and glutathione peroxidase) were significantly increased (p 4-treated mice; (v) histopathological damages in the liver from CCl4-treated mice were ameliorated by a pretreatment with BioSeNPs. In conclusion, these results have shown that BioSeNPs is able to protect the liver from CCl4-induced hepatic damage via increasing the antioxidant capacity and inhibiting oxidative damage. BioSeNPs may have the potential to be used as a trace element food supplement inducing antioxidant bioactivities. |
| اللغة: | English |
| تدمد: | 2045-2322 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::085aab269ed8c3066725747071db11fcTest http://europepmc.org/articles/PMC5688085Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....085aab269ed8c3066725747071db11fc |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20452322 |
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