Low PAI-1 activity in relation to inflammatory parameters, insulin profile and body mass index
| العنوان: | Low PAI-1 activity in relation to inflammatory parameters, insulin profile and body mass index |
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| المؤلفون: | Anna Ågren, Björn Wiman, Sam Schulman |
| المصدر: | Journal of Internal Medicine. 264:586-592 |
| بيانات النشر: | Wiley, 2008. |
| سنة النشر: | 2008 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, medicine.medical_treatment, Hemorrhage, Body Mass Index, Young Adult, chemistry.chemical_compound, Insulin resistance, Internal medicine, Plasminogen Activator Inhibitor 1, Internal Medicine, Humans, Insulin, Medicine, Retrospective Studies, Proinsulin, C-Peptide, biology, Interleukin-6, business.industry, C-peptide, C-reactive protein, Age Factors, Case-control study, Retrospective cohort study, Middle Aged, medicine.disease, C-Reactive Protein, Logistic Models, Endocrinology, chemistry, Case-Control Studies, biology.protein, Female, business, Body mass index, Biomarkers |
| الوصف: | High plasminogen activator inhibitor type 1 (PAI-1) activity is associated with inflammatory reactions and insulin resistance, but it is unclear what regulates PAI-1 activity at the low end. The purpose of this study was to investigate if patients with low PAI-1 activity have a lack of inflammatory response or a low insulin level.Retrospective cohort study with internal controls.Sixty-three patients referred for investigation of bleeding tendency and with low PAI-1 activity were compared with 118 patients with normal or high PAI-1 activity.Levels of C-peptide, proinsulin, high-sensitivity C-reactive protein (hs-CRP) and interleukin-6 (IL-6). Adjustments were made for body mass index (BMI), oral oestrogens and age. Low PAI-1 activity was defined as less than 1 U mL(-1).Body mass index in the low normal range, oral oestrogens, young age and low C-peptide were significantly associated with low PAI-1 activity and there was a trend for association with IL-6 in univariable analysis. The effect of age disappeared after correction for oral oestrogens and the effect of C-peptide and IL-6 disappeared after further adjustments. Low BMI remained as the strongest predictor of low PAI-1 activity.Patients with bleeding tendency and low PAI-1 activity have inflammatory and insulin profiles similar to those with normal or high PAI-1, whereas BMI seems to be the most important determinant. |
| تدمد: | 1365-2796 0954-6820 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::081557dbd6329b5001c5b617a257b209Test https://doi.org/10.1111/j.1365-2796.2008.01999.xTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....081557dbd6329b5001c5b617a257b209 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13652796 09546820 |
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