Different effects of high-fat and high-sucrose diets on the physiology of perivascular adipose tissues of the thoracic and abdominal aorta
| العنوان: | Different effects of high-fat and high-sucrose diets on the physiology of perivascular adipose tissues of the thoracic and abdominal aorta |
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| المؤلفون: | Fumiaki Takeshita, Momoka Minami, Mayo Higashihara, Hirokazu Kawamoto, Kento Miyamoto, Hirona Kugo, Tsukasa Sasoh, Tatsuya Moriyama, Yuya Kondo, Nobuhiro Zaima |
| المصدر: | Adipocyte, Vol 10, Iss 1, Pp 412-423 (2021) Adipocyte article-version (VoR) Version of Record |
| بيانات النشر: | Taylor & Francis Group, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | High sucrose, Sucrose, medicine.medical_specialty, Histology, Physiology, Adipose tissue, Diet, High-Fat, Diseases of the endocrine glands. Clinical endocrinology, VASCULAR FUNCTIONS, Aneurysm, medicine.artery, Internal medicine, perivascular adipose tissue, Adipocytes, High fat, Medicine, QP1-981, Aorta, Abdominal, high-sucrose diet, QH573-671, business.industry, Abdominal aorta, High fat diet, Cell Biology, medicine.disease, RC648-665, Endocrinology, high-fat diet, Adipose Tissue, aneurysm, vascular diseases, business, Cytology, Research Article, Research Paper |
| الوصف: | Vascular diseases such as atherosclerosis and aneurysms are associated with diet. Perivascular adipose tissue (PVAT) was reportedly involved in the regulation of vascular functions. It is suggested that imbalanced diets can cause PVAT inflammation and dysfunction as well as impaired vascular function. However, the association between diets and PVAT are not clearly understood. Here, we showed that a high-fat and a high-sucrose diet affected PVAT at different sites. A high-fat diet induced increased number of large-sized lipid droplets and increased CD (Cluster of differentiation) 68+ macrophage- and monocyte chemotactic protein (MCP)-1-positive areas in the abdominal aortic PVAT (aPVAT). In addition, a high-fat diet caused decreased collagen fibre-positive area and increased CD68+ macrophage- and MCP-1-positive areas in the abdominal aorta. In contrast, a high-sucrose diet induced increased number of large-sized lipid droplets, increased CD68+ macrophage- and MCP-1-positive areas, and decreased UCP-1 positive area in the thoracic aortic PVAT (tPVAT). A high-sucrose diet caused decreased collagen fibre-positive area and increased CD68+ macrophage- and MCP-1-positive areas in the thoracic aorta. These results could be attributed to the different adipocyte populations in the tPVAT and aPVAT. Our results provide pathological evidence to improve our understanding of the relationship between diet and vascular diseases. |
| اللغة: | English |
| تدمد: | 2162-3945 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0786adc133899b7ff755a90439ed7f2fTest https://doaj.org/article/fdd12bc9d8b34487a51d10226c1f6232Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....0786adc133899b7ff755a90439ed7f2f |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 21623945 |
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