Author Correction: Evaluation of Hypoglycaemia with Non-Invasive Sensors in People with Type 1 Diabetes and Impaired Awareness of Hypoglycaemia
| العنوان: | Author Correction: Evaluation of Hypoglycaemia with Non-Invasive Sensors in People with Type 1 Diabetes and Impaired Awareness of Hypoglycaemia |
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| المؤلفون: | Kathrine Frey Frøslie, Ørjan G. Martinsen, Trond Jenssen, Hanne L. Gulseth, Marit R. Bjørgaas, Kåre I. Birkeland, Håvard Kalvøy, Christian Tronstad, Ole Elvebakk, Kristin Godang |
| المصدر: | Scientific Reports, Vol 9, Iss 1, Pp 1-2 (2019) Scientific Reports |
| بيانات النشر: | Nature Publishing Group, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Adult, Blood Glucose, Male, medicine.medical_specialty, Epinephrine, lcsh:Medicine, Sweating, Biosensing Techniques, medicine, Humans, Hypoglycemic Agents, Insulin, Author Correction, Intensive care medicine, lcsh:Science, Type 1 diabetes, Multidisciplinary, business.industry, Non invasive, lcsh:R, medicine.disease, Hypoglycemia, Diabetes Mellitus, Type 1, Glucose, ComputingMethodologies_DOCUMENTANDTEXTPROCESSING, Female, lcsh:Q, business |
| الوصف: | People with type 1 diabetes and impaired awareness of hypoglycaemia (IAH) are prone to severe hypoglycaemia. Previous attempts to develop non-invasive hypoglycaemia alarm systems have shown promising results, but it is not known if such alarms can detect severe hypoglycaemia in people with IAH. We aimed to explore whether a combination of non-invasive sensors could reliably evaluate hypoglycaemia (plasma glucose (PG) minimum 2.5 mmol/L) in people with IAH. Twenty participants with type 1 diabetes and IAH underwent randomly ordered, single blinded hyperinsulinemic euglycaemic and hyperinsulinemic hypoglycaemic clamps. Sweating, skin temperature, ECG, counterregulatory hormones and symptoms of hypoglycaemia were assessed. Overall, we were not able to detect clamp-induced hypoglycaemia with sufficient sensitivity and specificity for further clinical use. As a post-hoc analysis, we stratified participants according to their ability to identify hypoglycaemic symptoms during hypoglycaemic clamps. Five out of 20 participants could identify such symptoms. These participants had a significantly higher adrenaline response to hypoglycaemia (p 0.001) and were reliably identified by sensors. Based on our observations, a non-invasive alarm system based on measurement of sweating responses and ECG changes during hypoglycaemia might provide an alert at a plasma glucose concentration around 2.5 mmol/L if an adequate sympatho-adrenal reaction is elicited. |
| اللغة: | English |
| تدمد: | 2045-2322 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07494d37a7ec22db909dc98cf737f002Test http://link.springer.com/article/10.1038/s41598-019-42218-6Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....07494d37a7ec22db909dc98cf737f002 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20452322 |
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