Basal insulin ratio of type 1 diabetes
| العنوان: | Basal insulin ratio of type 1 diabetes |
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| المؤلفون: | Sumiko Yoshida, Munehide Matsuhisa, Yuko Akehi, Kiyoe Kurahashi, Masahiro Abe, Itsuro Endo, Yukari Mitsui, Hiroyasu Mori, Masashi Ishizu, Akio Kuroda, Ken-ichi Aihara, Takeshi Kondo |
| المصدر: | Journal of Diabetes Investigation, Vol 13, Iss 2, Pp 292-298 (2022) |
| بيانات النشر: | Wiley, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Blood Glucose, medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, 030209 endocrinology & metabolism, Bedtime, Diseases of the endocrine glands. Clinical endocrinology, Multiple daily insulin therapy, Body Mass Index, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Diabetes mellitus, Internal Medicine, medicine, Humans, Hypoglycemic Agents, Insulin, Basal insulin, In patient, 030212 general & internal medicine, Glycated Hemoglobin, Meal, Type 1 diabetes, Univariate analysis, business.industry, General Medicine, RC648-665, medicine.disease, Diabetes Mellitus, Type 1, Endocrinology, business, Body mass index |
| الوصف: | Aims/Introduction To investigate the basal insulin requirement in patients with type 1 diabetes who are on multiple daily injections (MDI) and to assess the patient characteristics that affect the percent of total daily basal insulin dose to the total daily insulin dose (%TBD/TDD). Materials and Methods The subjects of this study were 67 inpatients with type 1 diabetes who were served diabetic meals of 25–30 kcal/kg standard body weight during several weeks of hospitalization. The basal insulin requirement was adjusted to keep the blood glucose level from bedtime to before breakfast within a 30 mg/dL difference. The bolus insulin dose before the meal was adjusted to keep the blood glucose level below 140 and 200 mg/dL before and 2 h after each meal, respectively. The total daily insulin dose (TDD), the percent of total daily basal insulin dose (TBD) to TDD (%TBD/TDD), and clinical characteristics were collected. Results The median (Q1, Q3) of TDD was 33.0 (26.0, 49.0) units, and the %TBD/TDD was 24.1 ± 9.8%. The %TBD/TDD was positively correlated with the body mass index (BMI) and negatively correlated with the age at the onset and at the examination according to a univariate analysis. However, the %TBD/TDD was dependent on the BMI (β = 0.340, P = 0.004) and the age at examination (β = −0.288, P = 0.012) according to the multiple regression analysis. Conclusions The average %TBD/TDD in patients with type 1 diabetes on MDI was approximately 24% under inpatient conditions. The basal insulin requirement was dependent on the BMI and the age at examination. |
| وصف الملف: | application/pdf |
| تدمد: | 2040-1124 2040-1116 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06ba0ffe6f426bae850cd8f3d4932d95Test https://doi.org/10.1111/jdi.13547Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....06ba0ffe6f426bae850cd8f3d4932d95 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20401124 20401116 |
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