The effects of zinc deficiency on homeostasis of twelve minerals and trace elements in the serum, feces, urine and liver of rats
| العنوان: | The effects of zinc deficiency on homeostasis of twelve minerals and trace elements in the serum, feces, urine and liver of rats |
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| المؤلفون: | Maoqing Wang, Zixiang Li, Yanfeng Chen, Qingli Yu, Fan Wang, Lina Fan, Jiali Zhao, Lan Zhao, Yongzhi Sun, Xiaohan Sun |
| المصدر: | Nutrition & Metabolism, Vol 16, Iss 1, Pp 1-8 (2019) Nutrition & Metabolism |
| بيانات النشر: | BMC, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | medicine.medical_specialty, 030309 nutrition & dietetics, Endocrinology, Diabetes and Metabolism, Medicine (miscellaneous), chemistry.chemical_element, lcsh:TX341-641, Zinc, Urine, Excretion, 03 medical and health sciences, Internal medicine, medicine, ICP-MS, lcsh:RC620-627, Feces, 030304 developmental biology, 0303 health sciences, Minerals, Trace elements, Nutrition and Dietetics, Zinc deficiency, Chemistry, Reabsorption, Research, Renal Reabsorption, medicine.disease, lcsh:Nutritional diseases. Deficiency diseases, Endocrinology, Rat, lcsh:Nutrition. Foods and food supply, Homeostasis |
| الوصف: | Background Zinc deficiency can change the concentrations of minerals and trace elements in the body. However, previous studies still had many limitations. Objective To reveal the effects of zinc deficiency on homeostasis of 16 minerals and trace elements. Methods Forty-five rats were divided randomly into three groups: normal zinc diet (30 mg/kg), low zinc diet (10 mg/kg), and pair-fed diet(30 mg/kg). The concentrations of 16 minerals and trace elements in serum, feces, urine, and liver were measured by inductively coupled plasma mass spectrometry. The excretion of 16 elements in urine and feces were calculated and compared. Results Zinc-deficient rats exhibited significant changes in up to 12 minerals and trace elements. The low zinc diet induced decreased excretion of zinc and concentrations of zinc in serum, feces, urine, and liver. Zinc deficiency increased feces concentrations of Mg, Cu, Se, K, Ag, Fe and Mn; decreased the concentrations of Mg, Cu, Se, K in liver and urine, and a diminished amount of Ag was observed in serum. Decreased urinary concentrations of Zn Ca, Mg, Cu, Se, K, Na, As and Cr, suggested that zinc-deficient rats increased the 9 elements’ renal reabsorption. Decreased concentrations of Ca in liver, urine, and feces, decreased excretion in urine and feces and increased serum total Ca suggested that zinc deficiency increased the redistribution of Ca in serum or other tissues. Zinc deficiency increased excretion of Cu, Se, Fe; and decreased the excretion of other 8 elements except for Ag. Conclusions Zinc deficiency changed the excretion, reabsorption and redistribution of 12 minerals and trace elements in rats. Our findings are the first to show that zinc deficiency alters the concentrations of Ag, Cr, and As. Graphical abstract |
| اللغة: | English |
| تدمد: | 1743-7075 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06afb4e2b9a8386f335ccdf0e6cffc34Test http://link.springer.com/article/10.1186/s12986-019-0395-yTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....06afb4e2b9a8386f335ccdf0e6cffc34 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17437075 |
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