Metabolism pathways of arachidonic acids: mechanisms and potential therapeutic targets
| العنوان: | Metabolism pathways of arachidonic acids: mechanisms and potential therapeutic targets |
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| المؤلفون: | Bei Wang, Dao Wen Wang, Ingrid Fleming, Jiong Hu, Chen Chen, Lingli Dong, Lujin Wu, Jing Chen, Zheng Wen |
| المصدر: | Signal Transduction and Targeted Therapy, Vol 6, Iss 1, Pp 1-30 (2021) Signal Transduction and Targeted Therapy |
| بيانات النشر: | Nature Publishing Group, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | 0301 basic medicine, Cancer Research, Leukotrienes, lcsh:Medicine, Arachidonic Acids, Review Article, Pharmacology, medicine.disease_cause, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Phospholipase A2, Cytochrome P-450 Enzyme System, Genetics, medicine, Humans, lcsh:QH301-705.5, Cancer, chemistry.chemical_classification, biology, Cell Membrane, lcsh:R, Cytochrome P450, Metabolism, Lipoxygenases, Lipid Metabolism, Lipoxins, Metabolic pathway, Phospholipases A2, 030104 developmental biology, Enzyme, Cardiovascular diseases, chemistry, lcsh:Biology (General), Prostaglandin-Endoperoxide Synthases, 030220 oncology & carcinogenesis, biology.protein, Prostaglandins, Arachidonic acid, lipids (amino acids, peptides, and proteins), Signal transduction, Carcinogenesis, Metabolic Networks and Pathways |
| الوصف: | The arachidonic acid (AA) pathway plays a key role in cardiovascular biology, carcinogenesis, and many inflammatory diseases, such as asthma, arthritis, etc. Esterified AA on the inner surface of the cell membrane is hydrolyzed to its free form by phospholipase A2 (PLA2), which is in turn further metabolized by cyclooxygenases (COXs) and lipoxygenases (LOXs) and cytochrome P450 (CYP) enzymes to a spectrum of bioactive mediators that includes prostanoids, leukotrienes (LTs), epoxyeicosatrienoic acids (EETs), dihydroxyeicosatetraenoic acid (diHETEs), eicosatetraenoic acids (ETEs), and lipoxins (LXs). Many of the latter mediators are considered to be novel preventive and therapeutic targets for cardiovascular diseases (CVD), cancers, and inflammatory diseases. This review sets out to summarize the physiological and pathophysiological importance of the AA metabolizing pathways and outline the molecular mechanisms underlying the actions of AA related to its three main metabolic pathways in CVD and cancer progression will provide valuable insight for developing new therapeutic drugs for CVD and anti-cancer agents such as inhibitors of EETs or 2J2. Thus, we herein present a synopsis of AA metabolism in human health, cardiovascular and cancer biology, and the signaling pathways involved in these processes. To explore the role of the AA metabolism and potential therapies, we also introduce the current newly clinical studies targeting AA metabolisms in the different disease conditions. |
| اللغة: | English |
| تدمد: | 2059-3635 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::063891f5fb7a4801c10b11bd01327f43Test https://doaj.org/article/46018f62e17246b7b4a09effe2eea464Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....063891f5fb7a4801c10b11bd01327f43 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20593635 |
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