The First Examination of Diagnostic Performance of Automated Measurement of the Callosal Angle in 1856 Elderly Patients and Volunteers Indicates That 12.4% of Exams Met the Criteria for Possible Normal Pressure Hydrocephalus
| العنوان: | The First Examination of Diagnostic Performance of Automated Measurement of the Callosal Angle in 1856 Elderly Patients and Volunteers Indicates That 12.4% of Exams Met the Criteria for Possible Normal Pressure Hydrocephalus |
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| المؤلفون: | Stefan Bluml, J G McComb, Matthew Borzage, A. Saunders, J. Hughes, Kevin S. King |
| المصدر: | AJNR Am J Neuroradiol |
| بيانات النشر: | American Society of Neuroradiology (ASNR), 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Volunteers, Measurement variability, medicine.medical_specialty, business.industry, Neuroimaging, medicine.disease, Magnetic Resonance Imaging, Hydrocephalus, Normal Pressure, Corpus Callosum, Normal pressure hydrocephalus, Cohort, Humans, Medicine, Dementia, Biomarker (medicine), Radiology, Nuclear Medicine and imaging, In patient, Letters, Neurology (clinical), Radiology, Alzheimer's disease, business, Aged |
| الوصف: | Many patients with dementia may have comorbid or misdiagnosed normal pressure hydrocephalus, a treatable neurologic disorder. The callosal angle is a validated biomarker for normal pressure hydrocephalus with 93% diagnostic accuracy. Our purpose was to develop and evaluate an algorithm for automatically computing callosal angles from MR images of the brain.This article reports the results of analyzing callosal angles from 1856 subjects with 5264 MR images from the Open Access Series of Imaging Studies and the Alzheimer's Disease Neuroimaging Initiative databases. Measurement variability was examined between 2 neuroradiologists (The algorithm identified that 12.4% of subjects from these carefully screened cohorts had callosal angles of90°, a published threshold for possible normal pressure hydrocephalus. The intraclass correlation coefficient was 0.97 for agreement between neuroradiologists and 0.90 for agreement between manual and automatic measurement. The method was robust to different head orientations. The median coefficient of variation for repeat examinations was 4.2% (Q1 = 3.1%, Q3 = 5.8%). The simulated classification of normal pressure hydrocephalus versus Alzheimer using the automatic callosal angle had an accuracy, sensitivity, and specificity of 0.87 each.In even the most pristine research databases, analyses of the callosal angle indicate that some patients may have normal pressure hydrocephalus. The automatic callosal angle measurement can rapidly and objectively screen for normal pressure hydrocephalus in patients who would otherwise be misdiagnosed. |
| تدمد: | 1936-959X 0195-6108 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::060cc2693ba9c390093ff20362594f5aTest https://doi.org/10.3174/ajnr.a7294Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....060cc2693ba9c390093ff20362594f5a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1936959X 01956108 |
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