Serum β2-microglobulin levels in Coronavirus disease 2019 (Covid-19): Another prognosticator of disease severity?
| العنوان: | Serum β2-microglobulin levels in Coronavirus disease 2019 (Covid-19): Another prognosticator of disease severity? |
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| المؤلفون: | Reem S. Almaghrabi, Nicolaas Nagelkerke, Morad A. Alkaff, Maha Alamri, Mayyadah Alabdely, Walter Conca, Michael Warren Foster, Futwan Al-Mohanna, Faisal Albaiz |
| المصدر: | PLOS ONE, 16(3):e0247758 PLoS ONE, Vol 16, Iss 3, p e0247758 (2021) PLoS ONE |
| بيانات النشر: | Public Library of Science (PLoS), 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | RNA viruses, Male, 0301 basic medicine, Viral Diseases, Physiology, Coronaviruses, Comorbidity, Disease, Biochemistry, Severity of Illness Index, Gastroenterology, Cohort Studies, Pathogenesis, White Blood Cells, Medical Conditions, 0302 clinical medicine, Animal Cells, Medicine and Health Sciences, Coughing, Medicine, COVID-19, Ferritin, Respiratory failure, Viral transmission and infection, Lymphocytes, Virus testing, SARS-CoV-2, 030212 general & internal medicine, Pathology and laboratory medicine, Aged, 80 and over, Multidisciplinary, T Cells, Medical microbiology, Middle Aged, Prognosis, Hospitals, Infectious Diseases, Viruses, Cohort, Female, Cellular Types, SARS CoV 2, Pathogens, Research Article, Cohort study, Adult, medicine.medical_specialty, SARS coronavirus, Immune Cells, Science, Immunology, Saudi Arabia, Reference range, Microbiology, 03 medical and health sciences, Signs and Symptoms, Virology, Internal medicine, Severity of illness, Humans, Aged, Blood Cells, business.industry, Beta-2 microglobulin, Organisms, Viral pathogens, Biology and Life Sciences, Proteins, Protein Complexes, Covid 19, Cell Biology, medicine.disease, Microbial pathogens, Health Care, 030104 developmental biology, Health Care Facilities, Clinical Medicine, Physiological Processes, beta 2-Microglobulin, business, Viral Transmission and Infection, Biomarkers |
| الوصف: | β2-microglobulin (β2-m), a 11.8 kDa protein, pairs non-covalently with the α3 domain of the major histocompatibility class (MHC) I α-chain and is essential for the conformation of the MHC class I protein complex. Shed β2-m is measurable in circulation, and various disorders are accompanied by increases in β2-m levels, including several viral infections. Therefore, we explored whether β2-m levels could also be elevated in Coronavirus disease 2019 (Covid-19) and whether they predict disease severity. Serum β2-m levels were measured in a cohort of 34 patients infected with SARS-CoV-2 on admission to a tertiary care hospital in Riyadh, Saudi Arabia, as well as in an approximately age-sex matched group of 34 uninfected controls. Mean β2-m level was 3.25±1.68 mg/l (reference range 0.8–2.2 mg/l) in patients (mean age 48.2±21.6) and 1.98±0.61 mg/l in controls (mean age 48.2±21.6). 17 patients (mean age 36.9± 18.0) with mean β2-m levels of 2.27±0.64 mg/l had mild disease by WHO severity categorization, 12 patients (mean age 53.3±18.1) with mean β2-m levels of 3.57±1.39 mg/l had moderate disease, and five patients (of whom 2 died; mean age 74.4±13.8) with mean β2-m levels of 5.85±1.85 mg/l had severe disease (P < = 0.001, by ANOVA test for linear trend). In multivariate ordinal regression β2-m levels were the only significant predictor of disease severity. Our findings suggest that higher β2-m levels could be an early indicator of severity of disease and predict outcome of Covid-19. As the main limitations of the study are a single-center study, sample size and ethnicity, these results need confirmation in larger cohorts outside the Arabian Peninsula in order to delineate the value of β2-m measurements. The role of β2-m in the etiology and pathogenesis of severe Covid-19 remains to be elucidated. |
| تدمد: | 1932-6203 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05d01654f6dcb4ba7d2cecfbaa820939Test https://doi.org/10.1371/journal.pone.0247758Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....05d01654f6dcb4ba7d2cecfbaa820939 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19326203 |
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